Soltani Moghaddam Reza, Medghalchi Abdolreza, Alizadeh Yousef
Department of Ophthalmology, Eye Research Center, Guilan University of Medical Sciences, Rasht, Iran.
Acta Med Iran. 2017 Jan;55(1):24-28.
. To investigate the effect of anisometropic and strabismic amblyopia on the nerve fiber layer thickness. This cross-sectional study was done on 54 amblyopic subjects, equally in both strabismic and anisometropic groups. The thickness otonerve fiber layer measured in superior, inferior, nasal, temporal quadrants and as a whole in both eyes of both groups. The means of thickness were compared in amblyopic and sound eyes. In strabismus group, the average nerve fiber layer thickness of the sound eye , in superior, inferior, nasal and temporal quadrants and as a whole were 113.23±14, 117.37±25, 68.96±6, 69.55±14 and 93.40±8 microns respectively. In amblyopic eyes of the same group, these measurements were 103.11±18, 67.74±11, and 69.59±16 and 89.59±12 microns in superior, inferior, nasal, temporal quadrants and as whole respectively. In anisometropic groups, the sound eye measurements were as 130.96±22, 129.07±29, 80.62±12, and 83.88±20 and 107.7±13 microns in superior, inferior, nasal and temporal quadrants and as a whole orderly. In amblyopic eyes of this group the mean thicknesses were 115.63±29, 133.15±25, 78.8±15, 80.2±16 and 109.17±21 microns in superior, inferior, nasal, temporal quadrants and as a whole respectively. Statistically, there were no significant differences between amblyopic and sound eyes (P>0.5). Our study did not support any significant change in a nerve fiber layer thickness of amblyopic patients; however, decreased thickness in superior and nasal quadrants of strabismic amblyopia and except inferior quadrant and as a whole. These measurements may be a clue for management and prognosis of amblyopia in old age.
研究屈光参差性弱视和斜视性弱视对神经纤维层厚度的影响。本横断面研究对54例弱视患者进行，斜视组和屈光参差组人数相等。测量两组患者双眼上、下、鼻、颞象限以及整体的神经纤维层厚度。比较弱视眼和正常眼的厚度均值。在斜视组，正常眼上、下、鼻、颞象限以及整体的神经纤维层平均厚度分别为113.23±14、117.37±25、68.96±6、69.55±14和93.40±8微米。在同一组的弱视眼中，这些测量值在上、下、鼻、颞象限以及整体分别为103.11±18、67.74±11、69.59±16和89.59±12微米。在屈光参差组，正常眼上、下、鼻、颞象限以及整体的测量值依次为130.96±22、129.07±29、80.62±12、83.88±20和107.7±13微米。在该组弱视眼中，上、下、鼻、颞象限以及整体的平均厚度分别为115.63±29、133.15±25、78.8±15、80.2±16和109.17±21微米。统计学上，弱视眼和正常眼之间无显著差异（P>0.5）。我们的研究不支持弱视患者神经纤维层厚度有任何显著变化；然而，斜视性弱视的上象限和鼻象限厚度降低，下象限及整体除外。这些测量结果可能为老年弱视的治疗和预后提供线索。
