Sahin Gözde, Dal Derya
Ophthalmology Department, Erzurum Region Training and Research Hospital, Erzurum, Turkey.
Graefes Arch Clin Exp Ophthalmol. 2019 Oct;257(10):2103-2110. doi: 10.1007/s00417-019-04402-2. Epub 2019 Jul 4.
To detect retinal nerve fiber layer thickness differences of ambylopic and fellow eyes and ambylopic and control eyes.
The study comprised a total of 152 eyes recruited from Erzurum Region Training and Research Hospital, Turkey, between January 2018 and May 2018. Anisometropic amblyopia was the only cause of disability (visual acuity ≤ 6/12 and a difference in best-corrected visual acuity (BCVA) between the two eyes of 0.20 logMAR (2 lines on an acuity chart) in amblyopic eyes (n, 74) whereas normal eyes had a best-corrected visual acuity of 6/6 and no morbidities (n, 78). Anisometropic patients were divided into three groups as hyperopic, myopic, and cylindiric. All amblyopic eyes were compared with fellow eye and control group. Retinal nerve fiber layer thickness was analyzed using optic coherence tomography (OCT) (RTVue 100-2, Optovue, Inc. Fremont, CA).
The mean age of the patients was 28.64 ± 8.23 years in amblyopia group and 32.23 ± 8.14 years in control group (p, 0.008). Mean best-corrected visual acuity (BCVA) was 0.36 ± 0.23 in amblyopic eyes, 0.96 ± 0.15 in fellow eyes, and 1.00 ± 0 in control group. Mean refractive error was 2.76 ± 7.84 in amblyopic eyes, 0.42 ± 1.34 in fellow eyes, and 0.12 ± 0.27 in control group. Temporal retinal nerve fiber layer thickness (RNFL-T) was 77.27 ± 10.38 μ, 79.31 ± 9.53 μ, and 81.46 ± 9.86 μ respectively in ambylopic group, fellow eyes, and control eyes (p, 0.036). Superior RNFL-T was 136.23 ± 18.52 μ, 131.91 ± 13.80 μ, and 135.56 ± 14.94 μ respectively in ambylopic group, fellow eyes, and control eyes (p, 0.204). Nasal RNFL-T was 87.99 ± 13.05 μ, 82.16 ± 12.33 μ, and 85.50 ± 10.62 μ respectively in ambylopic group, fellow eyes, and control eyes (p, 0.014). Inferior RNFL-T was 144.85 ± 18.39 μ, 140.55 ± 16.92 μ, and 143.47 ± 17.75 μ respectively in ambylopic group, fellow eyes, and control eyes (p, 0.322). There was statistically significant difference in temporal and nasal quadrants and no statistical difference in superior and inferior quadrants.
The presence of amblyopia seems not to be related with RNFL-T so we could ignore anisometropic amblyopia in patients with disease that could be detected and followed via RNFL thickness. Further and larger scaled studies are needed for certain results.
检测弱视眼与对侧眼以及弱视眼与对照组眼之间视网膜神经纤维层厚度的差异。
本研究共纳入2018年1月至2018年5月期间从土耳其埃尔祖鲁姆地区培训与研究医院招募的152只眼。屈光参差性弱视是唯一的致盲原因（弱视眼的视力≤6/12，且双眼最佳矫正视力（BCVA）相差0.20 logMAR（视力表上2行））（n = 74），而正常眼的最佳矫正视力为6/6且无疾病（n = 78）。屈光参差患者分为远视、近视和散光三组。将所有弱视眼与对侧眼及对照组进行比较。使用光学相干断层扫描（OCT）（RTVue 100 - 2，Optovue公司，弗里蒙特，加利福尼亚州）分析视网膜神经纤维层厚度。
弱视组患者的平均年龄为28.64±8.23岁，对照组为32.23±8.14岁（p = 0.008）。弱视眼的平均最佳矫正视力（BCVA）为0.36±0.23，对侧眼为0.96±0.15，对照组为1.00±0。弱视眼的平均屈光不正为2.76±7.84，对侧眼为0.42±1.34，对照组为0.12±0.27。弱视组、对侧眼和对照组的颞侧视网膜神经纤维层厚度（RNFL - T）分别为77.27±10.38μm、79.31±9.53μm和81.46±9.86μm（p = 0.036）。弱视组、对侧眼和对照组的上方RNFL - T分别为136.23±18.52μm、131.91±13.80μm和135.56±14.94μm（p = 0.204）。弱视组、对侧眼和对照组的鼻侧RNFL - T分别为87.99±13.05μm、82.16±12.33μm和85.50±10.62μm（p = 0.014）。弱视组、对侧眼和对照组的下方RNFL - T分别为144.85±18.39μm、140.55±16.92μm和143.47±17.75μm（p = 0.322）。颞侧和鼻侧象限存在统计学显著差异，上方和下方象限无统计学差异。
弱视的存在似乎与RNFL - T无关，因此在可通过RNFL厚度检测和随访的疾病患者中，我们可以忽略屈光参差性弱视。需要进一步开展更大规模的研究以得出确切结果。
