LaJoie Dollie, Ullman Katharine S
Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT 84112, USA.
Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT 84112, USA.
Curr Opin Cell Biol. 2017 Jun;46:39-45. doi: 10.1016/j.ceb.2016.12.008. Epub 2017 Feb 9.
Each time a metazoan cell undergoes open mitosis, the nucleus is dismantled in order to partition DNA content to the daughter cells. After chromosomes separate, changes at the chromatin surface usher in reestablishment of nuclear architecture. Proteins destined for the nuclear envelope are attracted to chromatin and concomitantly recruit membrane. As nuclear envelope and protein constituents spread to coat chromatin, distinct regions emerge-some rich in rapid pore formation, others occupied by microtubules that remain attached to kinetochores. Microtubule connections present physical barriers that must be remodeled in order for the nuclear envelope to seal. Regions of the nascent nuclear envelope that are initially characterized by contrasting repertoires of nuclear envelope proteins rapidly coalesce as nuclei expand and enter interphase.
每次后生动物细胞进行开放式有丝分裂时，细胞核都会解体，以便将DNA分配到子细胞中。染色体分离后，染色质表面的变化促使核结构重新建立。 destined for the nuclear envelope的蛋白质被吸引到染色质上，并随之招募膜。随着核膜和蛋白质成分扩散以覆盖染色质，不同的区域出现了——一些区域富含快速形成的核孔，另一些区域则被仍附着在动粒上的微管占据。微管连接形成了物理屏障，必须对其进行重塑，核膜才能封闭。新生核膜区域最初以核膜蛋白的不同组成特征为特点，随着细胞核扩张并进入间期，这些区域迅速融合。 （注：原文中“Proteins destined for the nuclear envelope”这里的“destined for”翻译得不太准确，可能需要结合更多背景知识来准确翻译，暂且保留原文表述。）
