State Key Laboratory of Oncology in South China; Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, 510060, China.
Department of Clinical Immunology, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510630, China.
Front Med. 2022 Jun;16(3):339-357. doi: 10.1007/s11684-022-0926-1. Epub 2022 Jun 27.
During mitosis, the allocation of genetic material concurs with organelle transformation and distribution. The coordination of genetic material inheritance with organelle dynamics directs accurate mitotic progression, cell fate determination, and organismal homeostasis. Small GTPases belonging to the Ras superfamily regulate various cell organelles during division. Being the key regulators of membrane dynamics, the dysregulation of small GTPases is widely associated with cell organelle disruption in neoplastic and non-neoplastic diseases, such as cancer and Alzheimer's disease. Recent discoveries shed light on the molecular properties of small GTPases as sophisticated modulators of a remarkably complex and perfect adaptors for rapid structure reformation. This review collects current knowledge on small GTPases in the regulation of cell organelles during mitosis and highlights the mediator role of small GTPase in transducing cell cycle signaling to organelle dynamics during mitosis.
在有丝分裂过程中，遗传物质的分配与细胞器的转化和分布一致。遗传物质的遗传与细胞器动力学的协调指导着有丝分裂的准确进行、细胞命运的决定和生物体的内稳态。属于 Ras 超家族的小 GTP 酶在分裂过程中调节各种细胞细胞器。作为膜动力学的关键调节剂，小 GTP 酶的失调与肿瘤和非肿瘤疾病（如癌症和阿尔茨海默病）中的细胞细胞器破坏广泛相关。最近的发现揭示了小 GTP 酶作为复杂而完美的适应物的分子特性，它们能够快速进行结构重构。这篇综述收集了目前关于小 GTP 酶在有丝分裂过程中调节细胞细胞器的知识，并强调了小 GTP 酶在将细胞周期信号转导到有丝分裂过程中的细胞器动力学中的中介作用。
