Heneghan C P, Thornton C, Navaratnarajah M, Jones J G
Br J Anaesth. 1987 Mar;59(3):277-82. doi: 10.1093/bja/59.3.277.
We have examined the effects of isoflurane (0.6-2.9% end-tidal) on the auditory evoked response (AER) in six patients before elective surgery. Isoflurane produced significant dose-related changes in the AER: reductions in amplitude and increases in latency of the cortical waves Pa and Nb, and increases in the latency of the brainstem waves III and V. When isoflurane was compared with halothane and enflurane using an MAC-based comparison, we found no differences in the effect of the three agents on the amplitude of the early cortical waves, although the latencies showed significant differences. The consistent dose-related effect on the amplitudes of the cortical waves implies that the AER could be a promising index of the depth of anaesthesia.
我们研究了异氟烷（呼气末浓度0.6 - 2.9%）对6例择期手术患者听觉诱发电位（AER）的影响。异氟烷使AER产生显著的剂量相关变化：皮层波Pa和Nb的波幅降低、潜伏期延长，以及脑干波III和V的潜伏期延长。当使用基于最低肺泡有效浓度（MAC）的比较方法将异氟烷与氟烷和恩氟烷进行比较时，我们发现三种药物对早期皮层波波幅的影响没有差异，尽管潜伏期存在显著差异。对皮层波波幅一致的剂量相关效应表明，AER可能是一种有前景的麻醉深度指标。
