Campesi Ilaria, Franconi Flavia, Seghieri Giuseppe, Meloni Marco
Department of Biomedical Sciences, University of Sassari, Sassari, Italy.
Department of Biomedical Sciences, University of Sassari, Sassari, Italy; Dipartimento Politiche della Persona, Regione Basilicata, Italy.
Pharmacol Res. 2017 May;119:195-207. doi: 10.1016/j.phrs.2017.01.023. Epub 2017 Feb 9.
Diabetes is a chronic disease associated with micro- and macrovascular complications and is a well-established risk factor for cardiovascular disease. Cardiovascular complications associated with diabetes are among the most important causes of death in diabetic patients. Interestingly, several sex-gender differences have been reported to significantly impact in the pathophysiology of diabetes. In particular, sex-gender differences have been reported to affect diabetes epidemiology, risk factors, as well as cardiovascular complications associated with diabetes. This suggests that different therapeutic approaches are needed for managing diabetes-associated cardiovascular complications in men and women. In this review, we will discuss about the sex-gender differences that are known to impact on diabetes, mainly focusing on the cardiovascular complications associated with the disease. We will then discuss the therapeutic approaches for managing diabetes-associated cardiovascular complications and how differences in sex-gender can influence the existing therapeutic approaches.
糖尿病是一种与微血管和大血管并发症相关的慢性疾病，是心血管疾病公认的危险因素。与糖尿病相关的心血管并发症是糖尿病患者最重要的死亡原因之一。有趣的是，据报道，一些性别差异会对糖尿病的病理生理学产生重大影响。特别是，据报道性别差异会影响糖尿病的流行病学、危险因素以及与糖尿病相关的心血管并发症。这表明，在治疗男性和女性与糖尿病相关的心血管并发症时需要采用不同的治疗方法。在这篇综述中，我们将讨论已知会影响糖尿病的性别差异，主要关注与该疾病相关的心血管并发症。然后，我们将讨论治疗与糖尿病相关的心血管并发症的治疗方法，以及性别差异如何影响现有的治疗方法。
