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1型和2型糖尿病患者进餐时胰岛素使用和浪费情况周围的行为、想法及认知:一项横断面调查研究

Behaviours, thoughts and perceptions around mealtime insulin usage and wastage among people with type 1 and type 2 diabetes mellitus: A cross-sectional survey study.

作者信息

Van Brunt Kate, Pedersini Riccardo, Rooney Jillian, Corrigan Sheila M

机构信息

Eli Lilly & Company Ltd, Erl Wood Manor, Sunninghill Road, Windlesham, Surrey GU20 6PH, UK.

Kantar Health, The Kirkgate, 19-31 Church Street, Epsom, Surrey KT17 4PF, UK; RTI Health Solutions, Travessera de Gracia 56, Ático 1(a), 08006 Barcelona, Spain.

出版信息

Diabetes Res Clin Pract. 2017 Apr;126:30-42. doi: 10.1016/j.diabres.2016.12.002. Epub 2016 Dec 18.

Abstract

AIMS

People with diabetes who use mealtime insulin (MTI) were surveyed about insulin wastage and injection habits when insufficient insulin remains in a disposable prefilled pen/cartridge to administer a full dose in a single injection.

METHODS

Cross-sectional, online, self-reported survey of MTI usage/wastage behaviour in 400 adults with type 1 (n=120) or type 2 (n=280) diabetes mellitus administering >20units/day of MTI via 100units/ml prefilled pens/cartridges for ⩾1month, conducted in France, Germany, Italy and UK.

RESULTS

Participants' mean±standard deviation age was 54.5±12.2years, body mass index was 29.9±7.2kg/m and duration of MTI therapy was 8.6±7.8years. They administered 3.7±5.9 injections/day with meals, using 11.3±18.0 prefilled pens/cartridges per month. Overall, 63.5% split the dose across two prefilled pens/cartridges (i.e. administered two injections to obtain a full dose), 15.0% used just what remained in their current pen (i.e. took a lower-than-prescribed dose) and 36.3% discarded prefilled pens/cartridges still containing insulin (i.e. took full dose with new pen). The latter participants discarded a mean 5.5±8.2 prefilled pens/cartridges monthly still containing insulin, each containing 8.6±8.7 units of insulin. Participants who wasted insulin considered it frustrating, time-consuming and painful to inject twice.

CONCLUSIONS

Patients taking >20units/day MTI can find transitions between insulin pens challenging. This study highlights the need to identify ways of improving transitions between pens to make transitions easier for insulin users, which could potentially improve adherence to prescribed doses and reduce waste.

摘要

目的

对使用餐时胰岛素(MTI)的糖尿病患者进行调查,了解当一次性预填充笔/笔芯内剩余胰岛素不足单次注射全剂量时的胰岛素浪费及注射习惯。

方法

在法国、德国、意大利和英国对400名1型(n = 120)或2型(n = 280)糖尿病成人患者进行横断面在线自我报告调查,这些患者每天通过100单位/毫升的预填充笔/笔芯注射超过20单位的MTI,疗程≥1个月。

结果

参与者的平均年龄±标准差为54.5±12.2岁,体重指数为29.9±7.2kg/m²,MTI治疗疗程为8.6±7.8年。他们每餐注射3.7±5.9次,每月使用11.3±18.0个预填充笔/笔芯。总体而言,63.5%的人将剂量分在两支预填充笔/笔芯中(即注射两次以获得全剂量),15.0%的人仅使用当前笔芯中剩余的胰岛素(即接受低于规定剂量),36.3%的人丢弃仍含有胰岛素的预填充笔/笔芯(即使用新笔芯注射全剂量)。后一组参与者每月平均丢弃5.5±8.2支仍含有胰岛素的预填充笔/笔芯,每支笔芯含有8.6±8.7单位胰岛素。浪费胰岛素的参与者认为注射两次令人沮丧、耗时且痛苦。

结论

每天注射超过20单位MTI的患者可能会发现胰岛素笔之间的转换具有挑战性。本研究强调需要找到改善笔之间转换的方法,使胰岛素使用者的转换更容易,这可能会提高对规定剂量的依从性并减少浪费。

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