中国猫杯状病毒分离株的遗传和系统发育分析。
Genetic and phylogenetic analysis of feline calicivirus isolates in China.
作者信息
Sun Yaxin, Deng Mingliang, Peng Zhong, Hu Ruiming, Chen Huanchun, Wu Bin
机构信息
Department of Preventive Veterinary Medicine, State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan 430070, China.
Department of Preventive Veterinary Medicine, State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan 430070, China.
出版信息
Vet J. 2017 Feb;220:24-27. doi: 10.1016/j.tvjl.2016.12.014. Epub 2016 Dec 21.
The aim of this study was to determine the genetic diversity of Chinese feline calicivirus (FCV) isolates and their phylogenetic relationship with isolates from elsewhere in the world. Phylogenetic analysis was performed based on the partial open reading frame (ORF) 2 sequences (regions B-F) of 21 Chinese FCV isolates and 30 global isolates. The Chinese isolates included 13 isolates from Wuhan, which were isolated in this study, and eight previously published isolates. Sixteen Chinese isolates and two Japanese isolates formed a distinct phylogenetic cluster. Phylogenetic analysis based on the sequences of the complete genome, ORF1, ORF2 and ORF3 of selected isolates supported the above findings. Genogroup analysis revealed that FCV genogroup II is present in China. These findings suggest that Chinese FCV isolates are closely related to Japanese FCV isolates.
本研究的目的是确定中国猫杯状病毒（FCV）分离株的遗传多样性及其与世界其他地区分离株的系统发育关系。基于21株中国FCV分离株和30株全球分离株的部分开放阅读框（ORF）2序列（B - F区）进行了系统发育分析。中国分离株包括本研究中从武汉分离的13株，以及8株先前发表的分离株。16株中国分离株和2株日本分离株形成了一个独特的系统发育簇。基于所选分离株的全基因组、ORF1、ORF2和ORF3序列的系统发育分析支持了上述发现。基因组分析表明中国存在FCV基因组II型。这些发现表明中国FCV分离株与日本FCV分离株密切相关。
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