Department of Veterinary Microbiology, College of Veterinary Medicine, Seoul National University, Seoul 08826, Korea.
Department of Biotechnology, Inje University, Gimhae 50834, Korea.
J Vet Sci. 2021 May;22(3):e32. doi: 10.4142/jvs.2021.22.e32. Epub 2021 Mar 18.
Feline calicivirus (FCV) is a highly infectious pathogen in cats and widely distributed worldwide with high genetic variation. Full-length open reading frame 2 of 5 from recently isolated Korean FCV isolates were sequenced and compared with those of global isolates. The results of phylogenetic analysis supported dividing global FCV isolates into two genogroups (type I and II) and demonstrated the presence of genogroup II in Korea, indicating their geographic spread in East Asia. High sequence variations in region E of the FCV isolates emphasizes that a novel vaccine needs to be developed to induce protective immunity against various FCV strains.
猫杯状病毒（FCV）是一种高度传染性的猫病原体，在全球范围内广泛分布，具有高度的遗传变异。对最近分离的韩国 FCV 分离株的全长开放阅读框 2 的 5 个进行测序，并与全球分离株进行比较。系统进化分析的结果支持将全球 FCV 分离株分为两个基因群（I 型和 II 型），并表明韩国存在基因群 II，表明其在东亚的地理传播。FCV 分离株中 E 区的高序列变异强调需要开发新型疫苗来诱导针对各种 FCV 株的保护性免疫。
