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气囊扩张术在胃底折叠术后吞咽困难管理中的作用。

The effect of pneumatic dilation in management of postfundoplication dysphagia.

作者信息

Sunjaya D, Podboy A, Blackmon S H, Katzka D, Halland M

机构信息

Division of Internal Medicine and Graduate Medical Education, Mayo Clinic, Rochester, MN, USA.

Division of Thoracic Surgery, Department of Surgery, Mayo Clinic, Rochester, MN, USA.

出版信息

Neurogastroenterol Motil. 2017 Jun;29(6). doi: 10.1111/nmo.13030. Epub 2017 Feb 12.

Abstract

BACKGROUND

Fundoplication surgery is a commonly performed procedure for gastro-esophageal reflux disease or hiatal hernia repair. Up to 10% of patients develop persistent postoperative dysphagia after surgery. Data on the effectiveness of pneumatic dilation for treatment are limited. The aim of this study was to evaluate clinical outcomes and identify clinical factors associated with successful response to pneumatic dilation among patients with persistent postfundoplication dysphagia (PPFD).

METHODS

We retrospectively evaluated patients who had undergone pneumatic dilation for PPFD between 1999 and 2016. Patients with dysphagia or achalasia prior to fundoplication were excluded. Demographic information, surgical history, severity of dysphagia, and clinical outcomes were collected. Data pertaining to esophagram, manometry, endoscopy, and pneumatic dilation were also collected.

RESULTS

We identified 38 patients (82% female, 95% Caucasian, and median age 59 years) with PPFD who completed pneumatic dilation. The median postfundoplication dysphagia score was 2. Eleven patients had abnormal peristalsis on manometry. Seventeen patients reported response (seven complete) with an average decrease of 1 in their dysphagia score. Fifteen patients underwent reoperation due to PPFD. Hiatal hernia repair was the only factor that predicts a higher response rate to pneumatic dilation. Only one patient in our study developed complication (pneumoperitoneum) from pneumatic dilation.

CONCLUSION & INFERENCES: We found that pneumatic dilation to be a safe treatment option for PPFD with moderate efficacy. Patients who developed PPFD after a hiatal hernia repair may gain the greatest benefit after pneumatic dilation. We were not able to identify additional clinical, radiological, endoscopic, or manometric parameters that were predictive of response.

摘要

背景

胃底折叠术是治疗胃食管反流病或食管裂孔疝修补的常用手术。高达10%的患者术后会出现持续性吞咽困难。关于气囊扩张治疗效果的数据有限。本研究的目的是评估临床结局,并确定胃底折叠术后持续性吞咽困难(PPFD)患者对气囊扩张成功反应相关的临床因素。

方法

我们回顾性评估了1999年至2016年间因PPFD接受气囊扩张的患者。排除胃底折叠术前有吞咽困难或贲门失弛缓症的患者。收集人口统计学信息、手术史、吞咽困难严重程度和临床结局。还收集了与食管造影、测压、内镜检查和气囊扩张相关的数据。

结果

我们确定了38例完成气囊扩张的PPFD患者(82%为女性,95%为白种人,中位年龄59岁)。胃底折叠术后吞咽困难评分中位数为2。11例患者测压显示蠕动异常。17例患者报告有反应(7例完全缓解),吞咽困难评分平均降低1分。15例患者因PPFD接受再次手术。食管裂孔疝修补是预测气囊扩张反应率较高的唯一因素。我们研究中只有1例患者因气囊扩张出现并发症(气腹)。

结论与推论

我们发现气囊扩张是治疗PPFD的一种安全的治疗选择,疗效中等。食管裂孔疝修补术后发生PPFD的患者可能在气囊扩张后获益最大。我们无法确定其他可预测反应的临床、放射学、内镜或测压参数。

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