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食管气囊扩张术治疗胃底折叠术后吞咽困难:安全性、有效性及预后预测因素

Esophageal pneumatic dilation for postfundoplication dysphagia: safety, efficacy, and predictors of outcome.

作者信息

Hui J M, Hunt D R, de Carle D J, Williams R, Cook I J

机构信息

Departments of Gastroenterology, and Upper GI Surgery, The St. George Hospital, University of New South Wales, Sydney, Australia.

出版信息

Am J Gastroenterol. 2002 Dec;97(12):2986-91. doi: 10.1111/j.1572-0241.2002.07115.x.

Abstract

OBJECTIVE

Persistent dysphagia occurs in 5-10% of patients after fundoplication. The cause is obscure in most cases, and the management has not been well established. The aim of this study is to evaluate the clinical outcomes and the predictors of success for esophageal pneumatic dilations in patients with dysphagia after fundoplication.

METHODS

We retrospectively reviewed 14 patients who underwent pneumatic dilation for persistent postfundoplication dysphagia. All patients had esophageal manometry before dilations.

RESULTS

There were nine responders to pneumatic dilations (30-40-mm balloons). The nadir lower esophageal sphincter (LES) relaxation pressure was the only significant predictor for successful dilation and was higher among the responders than nonresponders (median 10 mm Hg vs 5 mm Hg). All six of 14 patients with nadir LES pressure > or = 10 mm Hg had a good response. There was no significant difference in the LES basal pressure between the responders and nonresponders (median 20 mm Hg vs 12 mm Hg). The median distal peristaltic amplitude (74 mm Hg vs 69 mm Hg), percent of failed peristalsis (8% vs 45%), and ramp pressure (19 mm Hg vs 17 mm Hg) did not differ significantly between the responders and nonresponders. No perforations occurred.

CONCLUSIONS

Pneumatic dilation is a reasonably safe and effective treatment for patients with postfundoplication dysphagia. Raised nadir LES relaxation pressure seems to be a useful predictor of successful outcome.

摘要

目的

胃底折叠术后5%-10%的患者会出现持续性吞咽困难。多数情况下病因不明,且治疗方法尚未完全确立。本研究旨在评估胃底折叠术后吞咽困难患者行食管气囊扩张术的临床疗效及成功的预测因素。

方法

我们回顾性分析了14例行气囊扩张术治疗持续性胃底折叠术后吞咽困难的患者。所有患者在扩张术前均行食管测压。

结果

9例患者对气囊扩张术(30-40毫米球囊)有反应。最低食管下括约肌(LES)松弛压是扩张成功的唯一显著预测因素,有反应者的该压力高于无反应者(中位数分别为10毫米汞柱和5毫米汞柱)。14例最低LES压力≥10毫米汞柱的患者中有6例反应良好。有反应者与无反应者的LES基础压力无显著差异(中位数分别为20毫米汞柱和12毫米汞柱)。有反应者与无反应者的远端蠕动幅度中位数(74毫米汞柱对69毫米汞柱)、蠕动失败百分比(8%对45%)和斜坡压(19毫米汞柱对17毫米汞柱)无显著差异。未发生穿孔。

结论

气囊扩张术是治疗胃底折叠术后吞咽困难患者的一种相对安全有效的方法。升高的最低LES松弛压似乎是成功治疗结果的一个有用预测因素。

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