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连接多能性重编程与癌症。

Linking Pluripotency Reprogramming and Cancer.

机构信息

Synpromics Ltd., Edinburgh, United Kingdom.

StemTek Therapeutics, Bilbao, Spain.

出版信息

Stem Cells Transl Med. 2017 Feb;6(2):335-339. doi: 10.5966/sctm.2015-0225. Epub 2016 Sep 20.

DOI:10.5966/sctm.2015-0225
PMID:28191771
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5442824/
Abstract

Tumor development and the generation of induced pluripotent stem cells are highly comparable processes with striking similarities. Cellular plasticity is inherent to tumor evolution, rendering cells that acquire a stem cell-like phenotype, for which Sox2 activation has proved instrumental for the plastic acquisition of stemness properties in tumor cells. Understanding the molecular mechanisms underlying both events might uncover novel approaches for the development of anticancer therapeutics and constitute model systems for understanding tumor generation and ensuring the biosafety of cell-based therapies. Stem Cells Translational Medicine 2017;6:335-339.

摘要

肿瘤的发生发展与诱导多能干细胞的产生是高度可比的过程，存在显著的相似性。细胞可塑性是肿瘤演进所固有的，使获得类似干细胞表型的细胞，其中 Sox2 的激活已被证明对肿瘤细胞获得干性特性的可塑性获得是至关重要的。了解这两个事件的分子机制可能会为开发抗癌治疗方法提供新的途径，并构成理解肿瘤发生和确保基于细胞治疗的生物安全性的模型系统。《Stem Cells Translational Medicine》2017 年 6 月；6：335-339.

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c49/5442824/3bbb9f791876/SCT3-6-335-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c49/5442824/8ad1fbc139cd/SCT3-6-335-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c49/5442824/3bbb9f791876/SCT3-6-335-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c49/5442824/8ad1fbc139cd/SCT3-6-335-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c49/5442824/3bbb9f791876/SCT3-6-335-g002.jpg

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Oncotarget. 2015 Apr 30;6(12):10366-73. doi: 10.18632/oncotarget.3590.
2
Metabostemness: Metaboloepigenetic reprogramming of cancer stem-cell functions.代谢干性：癌症干细胞功能的代谢表观遗传重编程。
Oncoscience. 2014 Dec 26;1(12):803-6. doi: 10.18632/oncoscience.113. eCollection 2014.
3
A flexible reporter system for direct observation and isolation of cancer stem cells.
解锁细胞可塑性：通过溴结构域抑制和细胞外基质基因表达调控增强人 iPSC 重编程。
Stem Cells. 2024 Aug 1;42(8):706-719. doi: 10.1093/stmcls/sxae039.
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Restricting epigenetic activity promotes the reprogramming of transformed cells to pluripotency in a line-specific manner.限制表观遗传活性以细胞系特异性方式促进转化细胞重编程为多能性。
Cell Death Discov. 2023 Jul 14;9(1):245. doi: 10.1038/s41420-023-01533-8.
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