Department of Chemistry "Ugo Schiff" and CSGI, University of Florence , via della Lastruccia 3, 50019 Sesto Fiorentino, Florence, Italy.
Department of Chemistry and Chemical Engineering, Chalmers University of Technology , 41296 Göteborg, Sweden.
Langmuir. 2017 Mar 7;33(9):2411-2419. doi: 10.1021/acs.langmuir.6b04414. Epub 2017 Feb 22.
Aluminum oxide surfaces are of utmost interest in different biotech applications, in particular for their use as adjuvants (i.e., booster of the immune response against infectious agents in vaccines production). In this framework, imogolite clays combine the chemical flexibility of an exposed alumina surface with 1D nanostructure. This work reports on the interaction between amino acids and imogolite, using turbidimetry, ζ-potential measurements, and Fourier transform infrared spectroscopy as main characterization tools. Amino acids with different side chain functional groups were investigated, showing that glutamic acid (Glu) has the strongest affinity for the imogolite surface. This was exploited to prepare a composite material made of a synthetic surfactant bearing a Glu polar head and a hydrophobic C alkyl tail, adsorbed onto the surface of imogolite. The adsorption of a model drug (rhodamine B isothiocyanate) by the hybrid was evaluated both in water and in physiological saline conditions. The findings of this paper suggest that the combination between the glutamate headgroup and imogolite represents a promising platform for the fabrication of hybrid nanostructures with tailored functionalities.
氧化铝表面在不同的生物技术应用中非常重要，特别是作为佐剂（即疫苗生产中对抗感染剂的免疫反应的增强剂）。在这一框架内，埃洛石粘土将暴露的氧化铝表面的化学灵活性与 1D 纳米结构结合在一起。本工作报告了氨基酸与埃洛石之间的相互作用，主要采用浊度法、ζ-电位测量和傅里叶变换红外光谱作为主要的表征工具。研究了具有不同侧链官能团的氨基酸，表明谷氨酸（Glu）与埃洛石表面具有最强的亲和力。利用这一性质，制备了一种由带有 Glu 极性头和疏水 C 烷基尾的合成表面活性剂组成的复合材料，吸附在埃洛石表面上。在水和生理盐水条件下，评估了模型药物（罗丹明 B 异硫氰酸酯）在该复合材料上的吸附。本文的研究结果表明，谷氨酸头基与埃洛石的结合代表了一种很有前途的平台，可以用于制备具有定制功能的混合纳米结构。
