Comprehensive Weight Control Center, Division of Endocrinology, Diabetes and Metabolism, Weill Cornell Medical College, New York, New York.
Comprehensive Weight Control Center, Division of Endocrinology, Diabetes and Metabolism, Weill Cornell Medical College, New York, New York.
Gastroenterology. 2017 May;152(7):1765-1779. doi: 10.1053/j.gastro.2016.12.049. Epub 2017 Feb 10.
Obesity management requires a multidisciplinary approach, as there are many factors that contribute to the development of obesity, as well as the preservation of excess weight once it has been gained. Diet, exercise, and behavior modification are key components of treatment. In addition to lifestyle changes, weight gain secondary to medications is an important modifiable risk factor. Even after appropriate lifestyle modification, and medication adjustments (where possible) to avoid agents that can contribute to weight gain, many patients are still unable to achieve clinically meaningful weight loss. Pharmacotherapy for obesity management can fill an important role for these patients. This article will review medications that can lead to weight gain and potential alternatives, currently approved anti-obesity medications and best practices to individualize the selection process, and the use of testosterone in men with hypogonadism and obesity.
肥胖管理需要多学科的方法，因为有许多因素会导致肥胖的发展，以及一旦体重增加就难以维持。饮食、运动和行为改变是治疗的关键组成部分。除了生活方式的改变外，药物引起的体重增加也是一个重要的可改变的危险因素。即使在适当的生活方式改变和药物调整（在可能的情况下）以避免导致体重增加的药物后，许多患者仍然无法实现临床意义上的体重减轻。肥胖管理的药物治疗可以为这些患者提供重要的帮助。本文将回顾可能导致体重增加的药物以及潜在的替代品，目前批准的抗肥胖药物以及个性化选择过程的最佳实践，以及在患有性腺功能减退和肥胖的男性中使用睾酮。
