含胆固醇脂质双层比热中热异常的理论。
Theory of thermal anomalies in the specific heat of lipid bilayers containing cholesterol.
作者信息
Ipsen J H, Mouritsen O G, Zuckermann M J
机构信息
Department of Structural Properties of Materials, Technical University of Denmark, Lyngby.
出版信息
Biophys J. 1989 Oct;56(4):661-7. doi: 10.1016/S0006-3495(89)82713-4.
Abstract
A theoretical explanation of the experimentally observed characteristic thermal anomalies in the specific heat of lipid bilayers containing cholesterol is provided in terms of the phase equilibria in the phosphatidylcholine-cholesterol system. The phase equilibria are calculated via a microscopic interaction model that takes proper account of both the conformational and the crystalline degrees of freedom of the lipid acyl chains. It is shown that the characteristic double-peaked specific heat, with a narrow and a broad component, is a natural consequence of the topology of the phase diagram. Some results for the enthalpy of the mixed system are also reported. It is suggested that there is no need for invoking special mechanisms such as lipid-cholesterol complexing or formation of special interfacial regions in the bilayer in order to explain the specific-heat anomalies.
摘要
根据磷脂酰胆碱 - 胆固醇系统中的相平衡，对含胆固醇的脂质双层比热实验观测到的特征热异常现象给出了理论解释。通过一个微观相互作用模型计算相平衡，该模型适当考虑了脂质酰基链的构象自由度和结晶自由度。结果表明，具有窄峰和宽峰成分的特征双峰比热是相图拓扑结构的自然结果。还报道了混合系统焓的一些结果。研究表明，无需引入特殊机制（如脂质 - 胆固醇络合或双层中特殊界面区域的形成）来解释比热异常现象。
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