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计算机自动化在儿童2型糖尿病诊断与管理中的有效性:一项随机临床试验

Effectiveness of Computer Automation for the Diagnosis and Management of Childhood Type 2 Diabetes: A Randomized Clinical Trial.

作者信息

Hannon Tamara S, Dugan Tamara M, Saha Chandan K, McKee Steven J, Downs Stephen M, Carroll Aaron E

机构信息

Indiana Children's Health Services Research, Department of Pediatrics, Indiana University School of Medicine, Indianapolis.

Department of Biostatistics, Indiana University School of Medicine, Indianapolis.

出版信息

JAMA Pediatr. 2017 Apr 1;171(4):327-334. doi: 10.1001/jamapediatrics.2016.4207.

Abstract

IMPORTANCE

Type 2 diabetes (T2D) is increasingly common in young individuals. Primary prevention and screening among children and adolescents who are at substantial risk for T2D are recommended, but implementation of T2D screening practices in the pediatric primary care setting is uncommon.

OBJECTIVE

To determine the feasibility and effectiveness of a computerized clinical decision support system to identify pediatric patients at high risk for T2D and to coordinate screening for and diagnosis of prediabetes and T2D.

DESIGN, SETTING, AND PARTICIPANTS: This cluster-randomized clinical trial included patients from 4 primary care pediatric clinics. Two clinics were randomized to the computerized clinical decision support intervention, aimed at physicians, and 2 were randomized to the control condition. Patients of interest included children, adolescents, and young adults 10 years or older. Data were collected from January 1, 2013, through December 1, 2016.

INTERVENTIONS

Comparison of physician screening and follow-up practices after adding a T2D module to an existing computer decision support system.

MAIN OUTCOMES AND MEASURES

Electronic medical record (EMR) data from patients 10 years or older were reviewed to determine the rates at which pediatric patients were identified as having a body mass index (BMI) at or above the 85th percentile and 2 or more risk factors for T2D and underwent screening for T2D.

RESULTS

Medical records were reviewed for 1369 eligible children (712 boys [52.0%] and 657 girls [48.0%]; median [interquartile range] age, 12.9 [11.2-15.3]), of whom 684 were randomized to the control group and 685 to the intervention group. Of these, 663 (48.4%) had a BMI at or above the 85th percentile. Five hundred sixty-five patients (41.3%) met T2D screening criteria, with no difference between control and intervention sites. The T2D module led to a significant increase in the percentage of patients undergoing screening for T2D (89 of 283 [31.4%] vs 26 of 282 [9.2%]; adjusted odds ratio, 4.6; 95% CI, 1.5-14.7) and a greater proportion attending a scheduled follow-up appointment (45 of 153 [29.4%] vs 38 of 201 [18.9%]; adjusted odds ratio, 1.8; 95% CI, 1.5-2.2).

CONCLUSIONS AND RELEVANCE

Use of a computerized clinical decision support system to automate the identification and screening of pediatric patients at high risk for T2D can help overcome barriers to the screening process. The support system significantly increased screening among patients who met the American Diabetes Association criteria and adherence to follow-up appointments with primary care clinicians.

TRIAL REGISTRATION

clinicaltrials.gov Identifier: NCT01814787.

摘要

重要性

2型糖尿病(T2D)在年轻人中越来越普遍。建议对患T2D风险很高的儿童和青少年进行一级预防和筛查,但在儿科初级保健机构中实施T2D筛查实践并不常见。

目的

确定计算机化临床决策支持系统用于识别T2D高危儿科患者以及协调糖尿病前期和T2D筛查与诊断的可行性和有效性。

设计、设置和参与者:这项整群随机临床试验纳入了来自4家儿科初级保健诊所的患者。两家诊所被随机分配到针对医生的计算机化临床决策支持干预组,另外两家被随机分配到对照组。感兴趣的患者包括10岁及以上的儿童、青少年和年轻人。数据收集时间为2013年1月1日至2016年12月1日。

干预措施

在现有计算机决策支持系统中添加T2D模块后,比较医生的筛查和随访实践。

主要结局和指标

对10岁及以上患者的电子病历(EMR)数据进行审查,以确定儿科患者被识别为体重指数(BMI)处于或高于第85百分位数且有2种或更多T2D风险因素并接受T2D筛查的比例。

结果

对1369名符合条件的儿童(712名男孩[52.0%]和657名女孩[48.0%];中位[四分位间距]年龄为12.9[11.2 - 15.3]岁)的病历进行了审查,其中684名被随机分配到对照组,685名被随机分配到干预组。其中,663名(48.4%)的BMI处于或高于第85百分位数。565名患者(41.3%)符合T2D筛查标准,对照组和干预组之间无差异。T2D模块使接受T2D筛查的患者比例显著增加(283名中的89名[31.4%]对282名中的26名[9.2%];调整后的优势比为4.6;95%置信区间为1.5 - 14.7),并且参加预定随访预约的比例更高(153名中的45名[29.4%]对201名中的38名[18.9%];调整后的优势比为1.8;95%置信区间为1.5 - 2.2)。

结论及相关性

使用计算机化临床决策支持系统自动识别和筛查T2D高危儿科患者有助于克服筛查过程中的障碍。该支持系统显著增加了符合美国糖尿病协会标准的患者的筛查率以及与初级保健临床医生随访预约的依从性。

试验注册

clinicaltrials.gov标识符:NCT0

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