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[基层医疗医生如何管理幽门螺杆菌感染患者?一项调查结果及其纳入2016年德国S2k指南的情况]

[How do primary care physicians manage their patients with Helicobacter pylori infection? Results of a survey and their implementation into the German S2k guideline 2016].

作者信息

Fischbach Wolfgang, Zerl Annemarie, Klassert Christine

机构信息

Medizinische Klinik II, Klinikum Aschaffenburg, Germany.

出版信息

Z Gastroenterol. 2017 Feb;55(2):136-139. doi: 10.1055/s-0042-119453. Epub 2017 Feb 13.

DOI:10.1055/s-0042-119453
PMID:28192846
Abstract

The German S3 guideline "H. pylori and gastroduodenal ulcer disease" clearly recommends how to diagnose H. pylori infection. It also states when and how eradication therapy should be done. However, there are only few data available on the management of these patients in daily routine. With this survey, we wanted to gather information on how primary care physicians are involved in the management of H. pylori infection and how they follow the guideline recommendations. From this, consequences for the update of the new S2k guideline 2016 and their communication should be derived.  A questionnaire with 16 items was sent to all registered primary care physicians in the district of Unterfranken, Germany. Of the 607 questionnaires sent out, 188 (31 %) were returned.  A test for H. pylori was induced in 76 % of cases with a history of ulcers, 66 % of dyspepsia, 55 % of a family history of gastric cancer, 54 % of unspecific abdominal discomfort, and 9 % and 6 % before initiating NSAID or ASS medication, respectively. Eighty-six percent of the physicians referred their patients to a gastroenterologist for further diagnostics, 45,8 % initiated eradication therapy by themselves, and 75 % and 25 % favored the French and Italian protocol, respectively. The majority did not consider a possible primary resistance to clarithromycine. Twenty-six percent did not regularly control the success of first-line eradication therapy. In case of control, the time intervals after end of eradication treatment are nearly always considered. Second-line therapy is initiated in 99 %, and its success is checked in 87 %.  Management of patients with H. pylori infection does not always follow the recommendations of current guidelines. The reasons for that were addressed in the formulation of the updated S2k guideline and will be communicated.

摘要

德国S3指南“幽门螺杆菌与胃十二指肠溃疡病”明确推荐了如何诊断幽门螺杆菌感染。它还说明了何时以及如何进行根除治疗。然而,关于这些患者在日常临床中的管理,可用数据很少。通过这项调查,我们希望收集有关初级保健医生如何参与幽门螺杆菌感染管理以及他们如何遵循指南建议的信息。由此,应得出对2016年新S2k指南更新及其传播的影响。一份包含16个项目的问卷被发送给德国下弗兰肯行政区所有注册的初级保健医生。在发出的607份问卷中,有188份(31%)被收回。在有溃疡病史的病例中,76%进行了幽门螺杆菌检测;消化不良病例中为66%;有胃癌家族史的病例中为55%;非特异性腹部不适病例中为54%;在开始使用非甾体抗炎药或阿司匹林药物之前,检测比例分别为9%和6%。86%的医生将患者转诊给胃肠病专家进行进一步诊断,45.8%的医生自行启动根除治疗,75%和25%的医生分别倾向于法国和意大利的治疗方案。大多数医生没有考虑到对克拉霉素可能存在的原发耐药性。26%的医生没有定期检查一线根除治疗的成功率。如果进行检查,几乎总是会考虑根除治疗结束后的时间间隔。99%的病例启动了二线治疗,87%的病例检查了二线治疗的成功率。幽门螺杆菌感染患者的管理并不总是遵循当前指南的建议。在更新的S2k指南制定过程中探讨了其原因,并将进行传达。

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