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幽门螺杆菌的诊断与治疗管理:德国私人执业胃肠病学家的一项调查

[Diagnostic and therapeutic management of helicobacter pylori: a survey among German gastroenterologists in private practice].

作者信息

Miehlke S, Loibl R, Meszaros S, Labenz J

机构信息

Magen-Darm-Zentrum, Facharztzentrum Eppendorf, Hamburg, Germany.

bng-Verbandsmanagement, Straubing, Germany.

出版信息

Z Gastroenterol. 2016 Oct;54(10):1130-1137. doi: 10.1055/s-0042-105654. Epub 2016 Oct 10.

Abstract

The acceptance and realization of clinical guidelines in daily routine practice is unknown. The aim of this study was to evaluate the behaviour of private gastroenterologists in Germany with respect to the diagnostic and therapeutic management of H. pylori infection in times of increasing antibiotic resistance. Between 12/2014 and 02/2015 a standardized questionnaire with 19 multiple choice questions were sent to 1507 private gastroenterologists in Germany. The data were electronically captured and analyzed using SurveyMonkey. The response rate was 36 % (540 questionnaires). 65 % of responders prescribe first line therapy by themselves and mainly use standard triple therapies. In patients with intolerance to penicillin, 81 % prescribe Italian triple therapy and 19 % prescribe bismuth quadruple therapy. Risk factors for primary clarithromycin resistance (migrational background, previous macrolide exposure) are routinely assessed by only a minority of responders (22 % and 17 %, respectively). Forty-one percent of responders perform eradication control by themselves mainly using a 13C urea breath test (54 %). In second line therapy, 42 % are prescribing bismuth quadruple therapy and 24 % fluoroquinolone triple therapy. After second line therapy, 58 % of responders are performing eradication control by themselves. Of those, 70 % always take biopsies for antibiotic susceptibility testing. The results of our survey suggest that most private gastroenterologists in Germany adhere to current guidelines for H. pylori management; however, some relevant deviations seem to exist. Our data might be useful for further developments of clinical guidelines and their communication among the medical community.

摘要

临床指南在日常实践中的接受程度和实际应用情况尚不清楚。本研究旨在评估德国私立胃肠病学家在抗生素耐药性不断增加的情况下,对幽门螺杆菌感染的诊断和治疗管理行为。2014年12月至2015年2月期间,向德国1507名私立胃肠病学家发送了一份包含19个多项选择题的标准化问卷。数据通过SurveyMonkey进行电子采集和分析。回复率为36%(540份问卷)。65%的回复者自行开具一线治疗方案,主要使用标准三联疗法。对于青霉素不耐受的患者,81%开具意大利三联疗法,19%开具铋剂四联疗法。只有少数回复者(分别为22%和17%)常规评估原发性克拉霉素耐药的危险因素(移民背景、既往大环内酯类药物暴露)。41%的回复者自行进行根除治疗效果评估,主要使用13C尿素呼气试验(54%)。在二线治疗中,42%开具铋剂四联疗法,24%开具氟喹诺酮三联疗法。二线治疗后,58%的回复者自行进行根除治疗效果评估。其中,70%总是进行活检以进行抗生素敏感性测试。我们的调查结果表明,德国大多数私立胃肠病学家遵循当前幽门螺杆菌管理指南;然而,似乎存在一些相关偏差。我们的数据可能有助于临床指南的进一步制定及其在医学界的传播。

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