摄入瞬时受体电位通道激动剂可减轻运动引起的肌肉痉挛。
Ingestion of transient receptor potential channel agonists attenuates exercise-induced muscle cramps.
作者信息
Craighead Daniel H, Shank Sean W, Gottschall Jinger S, Passe Dennis H, Murray Bob, Alexander Lacy M, Kenney W Larry
机构信息
Department of Kinesiology, Noll Laboratory, The Pennsylvania State University, University Park, Pennsylvania, 16802, USA.
Scout Consulting, LLC, Hebron, Illinois, USA.
出版信息
Muscle Nerve. 2017 Sep;56(3):379-385. doi: 10.1002/mus.25611. Epub 2017 May 9.
INTRODUCTION
Exercise-associated muscle cramping (EAMC) is a poorly understood problem that is neuromuscular in origin. Ingestion of transient receptor potential (TRP) channel agonists has been efficacious in attenuating electrically induced muscle cramps. This study examines the effect of TRP agonist ingestion on voluntarily induced EAMC and motor function.
METHODS
Study 1: Thirty-nine participants completed 2 trials after ingesting TRP agonist-containing active treatment (A), or vehicle (V) control. Cramping in the triceps surae muscle was induced via voluntary isometric contraction. Study 2: After ingesting A or V, 31 participants performed kinematic and psychomotor tests of manual dexterity.
RESULTS
A increased precramp contraction duration (A, 36.9 ± 4.1 s; V, 27.8 ± 3.1 s), decreased cramp EMG area under the curve (A, 37.3 ± 7.7 %EMG ·s; V, 77.2 ± 17.7 %EMG ·s), increased contraction force to produce the cramp (A, 13.8 ± 1.8 kg; V, 9.9 ± 1.6 kg), and decreased postcramp soreness (A, 4.1 ± 0.3 arbitrary units (a.u.); V, 4.7 ± 0.3 a.u.). Kinematic and psychomotor tests were not affected.
DISCUSSION
TRP agonist ingestion attenuated EAMC characteristics without affecting motor function. Muscle Nerve 56: 379-385, 2017.
引言
运动相关肌肉痉挛（EAMC）是一个起源于神经肌肉、但人们了解甚少的问题。摄入瞬时受体电位（TRP）通道激动剂对减轻电诱导的肌肉痉挛有效。本研究考察摄入TRP激动剂对自愿诱导的EAMC和运动功能的影响。
方法
研究1：39名参与者在摄入含TRP激动剂的活性治疗药物（A）或赋形剂（V）对照后完成2次试验。通过自愿等长收缩诱发腓肠肌痉挛。研究2：摄入A或V后，31名参与者进行了手部灵巧性的运动学和精神运动测试。
结果
A组增加了痉挛前收缩持续时间（A组，36.9±4.1秒；V组，27.8±3.1秒），减少了痉挛肌电图曲线下面积（A组，37.3±7.7%肌电图·秒；V组，77.2±17.7%肌电图·秒），增加了产生痉挛的收缩力（A组，13.8±1.8千克；V组，9.9±1.6千克），并减轻了痉挛后酸痛感（A组，4.1±0.3任意单位（a.u.）；V组，4.7±0.3 a.u.）。运动学和精神运动测试未受影响。
讨论
摄入TRP激动剂可减轻EAMC的特征，而不影响运动功能。《肌肉与神经》56: 379 - 385, 2017年。
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