过氧化物酶体作用于BAK：Bcl-2家族对过氧化物酶体完整性的调控
The peroxisomes strike BAK: Regulation of peroxisome integrity by the Bcl-2 family.
作者信息
Chipuk Jerry Edward, Luna-Vargas Mark P A
机构信息
Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029
Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029.
出版信息
J Cell Biol. 2017 Mar 6;216(3):547-549. doi: 10.1083/jcb.201701187. Epub 2017 Feb 13.
Within the mitochondrial pathway of apoptosis, VDAC2 controls both the localization and proapoptotic activity of BAK. In this issue, Hosoi et al. (2017. https://doi.org/10.1083/jcb.201605002) find that loss of VDAC2 diverts BAK into peroxisome membranes, revealing the ability of BAK to control peroxisome membrane integrity and the release of soluble peroxisomal matrix proteins.
在细胞凋亡的线粒体途径中，VDAC2控制BAK的定位和促凋亡活性。在本期中，细井等人（2017年。https://doi.org/10.1083/jcb.201605002）发现，VDAC2的缺失会使BAK转移到过氧化物酶体膜中，揭示了BAK控制过氧化物酶体膜完整性和可溶性过氧化物酶体基质蛋白释放的能力。
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