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过氧化物酶体作用于BAK：Bcl-2家族对过氧化物酶体完整性的调控

The peroxisomes strike BAK: Regulation of peroxisome integrity by the Bcl-2 family.

作者信息

Chipuk Jerry Edward, Luna-Vargas Mark P A

机构信息

Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029

Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029.

出版信息

J Cell Biol. 2017 Mar 6;216(3):547-549. doi: 10.1083/jcb.201701187. Epub 2017 Feb 13.

DOI:10.1083/jcb.201701187
PMID:28193702
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5350527/
Abstract

Within the mitochondrial pathway of apoptosis, VDAC2 controls both the localization and proapoptotic activity of BAK. In this issue, Hosoi et al. (2017. https://doi.org/10.1083/jcb.201605002) find that loss of VDAC2 diverts BAK into peroxisome membranes, revealing the ability of BAK to control peroxisome membrane integrity and the release of soluble peroxisomal matrix proteins.

摘要

在细胞凋亡的线粒体途径中，VDAC2控制BAK的定位和促凋亡活性。在本期中，细井等人（2017年。https://doi.org/10.1083/jcb.201605002）发现，VDAC2的缺失会使BAK转移到过氧化物酶体膜中，揭示了BAK控制过氧化物酶体膜完整性和可溶性过氧化物酶体基质蛋白释放的能力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b77c/5350527/b464c223922b/JCB_201701187_Fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b77c/5350527/b464c223922b/JCB_201701187_Fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b77c/5350527/b464c223922b/JCB_201701187_Fig1.jpg

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本文引用的文献

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The VDAC2-BAK axis regulates peroxisomal membrane permeability.电压依赖性阴离子通道2（VDAC2）-促凋亡蛋白BAK轴调节过氧化物酶体膜通透性。
J Cell Biol. 2017 Mar 6;216(3):709-722. doi: 10.1083/jcb.201605002. Epub 2017 Feb 7.
2
Physiological and Pharmacological Control of BAK, BAX, and Beyond.BAK、BAX及其他相关蛋白的生理与药理调控
Trends Cell Biol. 2016 Dec;26(12):906-917. doi: 10.1016/j.tcb.2016.07.002. Epub 2016 Aug 4.
3
Human disorders of peroxisome metabolism and biogenesis.人类过氧化物酶体代谢与生物发生紊乱。
Biochim Biophys Acta. 2016 May;1863(5):922-33. doi: 10.1016/j.bbamcr.2015.11.015. Epub 2015 Nov 22.
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Motifs of VDAC2 required for mitochondrial Bak import and tBid-induced apoptosis.线粒体Bak导入及tBid诱导凋亡所需的VDAC2基序。
Proc Natl Acad Sci U S A. 2015 Oct 13;112(41):E5590-9. doi: 10.1073/pnas.1510574112. Epub 2015 Sep 28.
5
Peroxisomes take shape.过氧化物酶体成形。
Nat Rev Mol Cell Biol. 2013 Dec;14(12):803-17. doi: 10.1038/nrm3700.
6
VDAC2 is required for truncated BID-induced mitochondrial apoptosis by recruiting BAK to the mitochondria.VDAC2 通过将 BAK 招募到线粒体中来介导截断型 BID 诱导的线粒体凋亡。
EMBO Rep. 2009 Dec;10(12):1341-7. doi: 10.1038/embor.2009.219. Epub 2009 Oct 9.
7
Relationship Between Catalase and Life Span in Recombinant Inbred Strains of Caenorhabditis elegans.秀丽隐杆线虫重组近交系中过氧化氢酶与寿命的关系
J Nematol. 2003 Sep;35(3):314-9.
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RAS-RAF-MEK-dependent oxidative cell death involving voltage-dependent anion channels.涉及电压依赖性阴离子通道的RAS-RAF-MEK依赖性氧化细胞死亡。
Nature. 2007 Jun 14;447(7146):864-8. doi: 10.1038/nature05859.
9
VDAC2 inhibits BAK activation and mitochondrial apoptosis.电压依赖性阴离子通道蛋白2抑制BAK激活和线粒体凋亡。
Science. 2003 Jul 25;301(5632):513-7. doi: 10.1126/science.1083995.
10
Newly identified Chinese hamster ovary cell mutants defective in peroxisome biogenesis represent two novel complementation groups in mammals.新发现的在过氧化物酶体生物合成中存在缺陷的中国仓鼠卵巢细胞突变体代表了哺乳动物中的两个新的互补群。
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