TRIM38在先天性免疫和炎症反应中的多方面作用。
Multifaceted roles of TRIM38 in innate immune and inflammatory responses.
作者信息
Hu Ming-Ming, Shu Hong-Bing
机构信息
Medical Research Institute, Collaborative Innovation Center for Viral Immunology, School of Medicine, Wuhan University, Wuhan 430071, China.
出版信息
Cell Mol Immunol. 2017 Apr;14(4):331-338. doi: 10.1038/cmi.2016.66. Epub 2017 Feb 13.
Abstract
The tripartite motif-containing (TRIM) proteins represent the largest E3 ubiquitin ligase family. The multifaceted roles of TRIM38 in innate immunity and inflammation have been intensively investigated in recent years. TRIM38 is essential for cytosolic RNA or DNA sensor-mediated innate immune responses to both RNA and DNA viruses, while negatively regulating TLR3/4- and TNF/IL-1β-triggered inflammatory responses. In these processes, TRIM38 acts as an E3 ubiquitin or SUMO ligase, which targets key cellular signaling components, or as an enzymatic activity-independent regulator. This review summarizes recent advances that highlight the critical roles of TRIM38 in the regulation of proper innate immune and inflammatory responses.
摘要
含三联基序（TRIM）的蛋白质是最大的E3泛素连接酶家族。近年来，TRIM38在固有免疫和炎症中的多方面作用得到了深入研究。TRIM38对于胞质RNA或DNA传感器介导的针对RNA和DNA病毒的固有免疫反应至关重要，同时对TLR3/4和TNF/IL-1β触发的炎症反应起负调节作用。在这些过程中，TRIM38作为E3泛素或SUMO连接酶，靶向关键的细胞信号成分，或作为一种不依赖酶活性的调节因子。本综述总结了近期的进展，这些进展突出了TRIM38在调节适当的固有免疫和炎症反应中的关键作用。
相似文献
1
Multifaceted roles of TRIM38 in innate immune and inflammatory responses.TRIM38在先天性免疫和炎症反应中的多方面作用。
Cell Mol Immunol. 2017 Apr;14(4):331-338. doi: 10.1038/cmi.2016.66. Epub 2017 Feb 13.
2
TRIM38 Negatively Regulates TLR3/4-Mediated Innate Immune and Inflammatory Responses by Two Sequential and Distinct Mechanisms.TRIM38通过两种连续且不同的机制负向调节TLR3/4介导的天然免疫和炎症反应。
J Immunol. 2015 Nov 1;195(9):4415-25. doi: 10.4049/jimmunol.1500859. Epub 2015 Sep 21.
3
TRIM38 negatively regulates TLR3-mediated IFN-β signaling by targeting TRIF for degradation.TRIM38 通过靶向 TRIF 降解来负调控 TLR3 介导的 IFN-β信号通路。
PLoS One. 2012;7(10):e46825. doi: 10.1371/journal.pone.0046825. Epub 2012 Oct 8.
4
E3 ubiquitin ligase tripartite motif 38 negatively regulates TLR-mediated immune responses by proteasomal degradation of TNF receptor-associated factor 6 in macrophages.E3 泛素连接酶三联基序蛋白 38 通过蛋白酶体降解巨噬细胞中的肿瘤坏死因子受体相关因子 6 来负调控 TLR 介导的免疫反应。
J Immunol. 2012 Mar 15;188(6):2567-74. doi: 10.4049/jimmunol.1103255. Epub 2012 Feb 8.
5
TRIM38 inhibits TNFα- and IL-1β-triggered NF-κB activation by mediating lysosome-dependent degradation of TAB2/3.TRIM38 通过介导 TAB2/3 的溶酶体依赖性降解来抑制 TNFα 和 IL-1β 触发的 NF-κB 激活。
Proc Natl Acad Sci U S A. 2014 Jan 28;111(4):1509-14. doi: 10.1073/pnas.1318227111. Epub 2014 Jan 13.
6
Emerging Roles of MHC Class I Region-Encoded E3 Ubiquitin Ligases in Innate Immunity.MHC Ⅰ类区编码 E3 泛素连接酶在固有免疫中的新兴作用。
Front Immunol. 2021 Jun 10;12:687102. doi: 10.3389/fimmu.2021.687102. eCollection 2021.
7
TRIM8 Negatively Regulates TLR3/4-Mediated Innate Immune Response by Blocking TRIF-TBK1 Interaction.TRIM8通过阻断TRIF-TBK1相互作用负向调节TLR3/4介导的天然免疫反应。
J Immunol. 2017 Sep 1;199(5):1856-1864. doi: 10.4049/jimmunol.1601647. Epub 2017 Jul 26.
8
Enterovirus 71 induces degradation of TRIM38, a potential E3 ubiquitin ligase.肠道病毒 71 诱导三结构域蛋白 38（TRIM38）降解，TRIM38 是一种潜在的 E3 泛素连接酶。
Virol J. 2011 Feb 10;8:61. doi: 10.1186/1743-422X-8-61.
9
Mechanisms and pathways of innate immune activation and regulation in health and cancer.健康与癌症中固有免疫激活和调节的机制与途径。
Hum Vaccin Immunother. 2014;10(11):3270-85. doi: 10.4161/21645515.2014.979640.
10
The Roles of TRIMs in Antiviral Innate Immune Signaling.TRIM 蛋白在抗病毒固有免疫信号中的作用。
Front Cell Infect Microbiol. 2021 Mar 15;11:628275. doi: 10.3389/fcimb.2021.628275. eCollection 2021.
引用本文的文献
1
Posttranslational modifications of YAP/TAZ: molecular mechanisms and therapeutic opportunities.YAP/TAZ的翻译后修饰：分子机制与治疗机遇
Cell Mol Biol Lett. 2025 Jul 17;30(1):83. doi: 10.1186/s11658-025-00760-4.
2
TRIM55 suppresses inflammatory response after spinal cord injury by accelerating the ubiquitination and degradation of TLR4.TRIM55通过加速Toll样受体4（TLR4）的泛素化和降解来抑制脊髓损伤后的炎症反应。
J Orthop Surg Res. 2025 May 26;20(1):517. doi: 10.1186/s13018-025-05922-w.
3
Characterization and Functional Analysis of Trim38 in the Immune Response of the Large Yellow Croaker () Against Infection.大黄鱼（Larimichthys crocea）免疫应答中Trim38的特性鉴定与功能分析：针对感染
Int J Mol Sci. 2025 Apr 27;26(9):4150. doi: 10.3390/ijms26094150.
4
TRIM proteins: A 'swiss army knife' of antiviral immunity.TRIM蛋白：抗病毒免疫的“瑞士军刀”。
PLoS Pathog. 2025 May 12;21(5):e1013147. doi: 10.1371/journal.ppat.1013147. eCollection 2025 May.
5
The Effector Protein BspF Crotonylates TRIM38 to Inhibit NF-κB and MAPK Signaling Pathway.效应蛋白BspF使TRIM38巴豆酰化以抑制NF-κB和MAPK信号通路。
Int J Mol Sci. 2025 Apr 10;26(8):3573. doi: 10.3390/ijms26083573.
6
Trim38 attenuates pressure overload‑induced cardiac hypertrophy by suppressing the TAK1/JNK/P38 signaling pathway.Trim38通过抑制TAK1/JNK/P38信号通路减轻压力超负荷诱导的心脏肥大。
Int J Mol Med. 2025 Jun;55(6). doi: 10.3892/ijmm.2025.5539. Epub 2025 May 2.
7
TRIM38 Suppresses the Progression of Colorectal Cancer via Enhancing CCT6A Ubiquitination to Inhibit the MYC Pathway.TRIM38通过增强CCT6A泛素化抑制MYC途径来抑制结直肠癌进展。
Adv Sci (Weinh). 2025 Apr;12(16):e2411285. doi: 10.1002/advs.202411285. Epub 2025 Mar 6.
8
TRIM38 Inhibits Zika Virus by Upregulating RIG-I/MDA5 Pathway and Promoting Ubiquitin-Mediated Degradation of Viral NS3 Protein.TRIM38通过上调RIG-I/MDA5信号通路及促进病毒NS3蛋白的泛素介导降解来抑制寨卡病毒。
Viruses. 2025 Jan 30;17(2):199. doi: 10.3390/v17020199.
9
UBE2G2 inhibits vasculogenic mimicry and metastasis of uveal melanoma by promoting ubiquitination of LGALS3BP.UBE2G2通过促进LGALS3BP的泛素化来抑制葡萄膜黑色素瘤的血管生成拟态和转移。
Acta Pharm Sin B. 2024 Dec;14(12):5201-5218. doi: 10.1016/j.apsb.2024.09.005. Epub 2024 Sep 13.
10
Transcriptome Analysis in Air-Liquid Interface Porcine Respiratory Epithelial Cell Cultures Reveals That the Betacoronavirus Porcine Encephalomyelitis Hemagglutinating Virus Induces a Robust Interferon Response to Infection.气液界面培养猪呼吸道上皮细胞的转录组分析显示，β冠状病毒猪传染性脑脊髓炎病毒感染诱导强烈的干扰素反应。
Viruses. 2024 Jun 11;16(6):939. doi: 10.3390/v16060939.
本文引用的文献
1
Delicate regulation of the cGAS-MITA-mediated innate immune response.精细调控 cGAS-MITA 介导的固有免疫反应。
Cell Mol Immunol. 2018 Jul;15(7):666-675. doi: 10.1038/cmi.2016.51. Epub 2018 Feb 19.
2
Innate immunity to RNA virus is regulated by temporal and reversible sumoylation of RIG-I and MDA5.对RNA病毒的天然免疫由RIG-I和MDA5的时序性及可逆性SUMO化修饰调控。
J Exp Med. 2017 Apr 3;214(4):973-989. doi: 10.1084/jem.20161015. Epub 2017 Mar 1.
3
Sumoylation Promotes the Stability of the DNA Sensor cGAS and the Adaptor STING to Regulate the Kinetics of Response to DNA Virus.SUMOylation 促进 DNA 传感器 cGAS 和衔接蛋白 STING 的稳定性，以调节对 DNA 病毒的反应动力学。
Immunity. 2016 Sep 20;45(3):555-569. doi: 10.1016/j.immuni.2016.08.014. Epub 2016 Sep 13.
4
iRhom2 is essential for innate immunity to DNA viruses by mediating trafficking and stability of the adaptor STING.iRhom2 通过介导衔接蛋白 STING 的运输和稳定性对于先天免疫 DNA 病毒是必不可少的。
Nat Immunol. 2016 Sep;17(9):1057-66. doi: 10.1038/ni.3510. Epub 2016 Jul 18.
5
MSX1 Modulates RLR-Mediated Innate Antiviral Signaling by Facilitating Assembly of TBK1-Associated Complexes.MSX1通过促进TBK1相关复合物的组装来调节RLR介导的先天性抗病毒信号传导。
J Immunol. 2016 Jul 1;197(1):199-207. doi: 10.4049/jimmunol.1600039. Epub 2016 May 18.
6
Mex3B: a coreceptor to present dsRNA to TLR3.Mex3B：一种将双链RNA呈递给TLR3的共受体。
Cell Res. 2016 Apr;26(4):391-2. doi: 10.1038/cr.2016.29. Epub 2016 Mar 4.
7
Glutamylation of the DNA sensor cGAS regulates its binding and synthase activity in antiviral immunity.谷氨酸化的 DNA 感应器 cGAS 调控其在抗病毒免疫中的结合和合成酶活性。
Nat Immunol. 2016 Apr;17(4):369-78. doi: 10.1038/ni.3356. Epub 2016 Feb 1.
8
The RNA-binding protein Mex3B is a coreceptor of Toll-like receptor 3 in innate antiviral response.RNA结合蛋白Mex3B是天然抗病毒反应中Toll样受体3的共受体。
Cell Res. 2016 Mar;26(3):288-303. doi: 10.1038/cr.2016.16. Epub 2016 Jan 29.
9
Brief Report: Patients With Primary Sjögren's Syndrome Who Are Positive for Autoantibodies to Tripartite Motif-Containing Protein 38 Show Greater Disease Severity.简要报告：抗三磷酸鸟苷结合蛋白 38 自身抗体阳性原发性干燥综合征患者疾病严重程度更高。
Arthritis Rheumatol. 2016 Mar;68(3):724-9. doi: 10.1002/art.39497.
10
STING: infection, inflammation and cancer.干扰素基因刺激蛋白：感染、炎症与癌症
Nat Rev Immunol. 2015 Dec;15(12):760-70. doi: 10.1038/nri3921.
Zotero 插件