Graduate School of Sciences and Technology for Innovation, Yamaguchi University , Yamaguchi 753-8512, Japan.
J Org Chem. 2017 Mar 3;82(5):2664-2671. doi: 10.1021/acs.joc.6b03058. Epub 2017 Feb 22.
The synthesis of alkylated pyrimidines was achieved via benzophenone-mediated photoinduced coupling between saturated heterocycles and sulfonylpyrimidines. The pyrimidine ring was selectively introduced at the nonacidic C(sp)-H bond proximal to heteroatoms including oxygen, nitrogen, and sulfur. This is a coupling reaction mediated solely by photoexcited benzophenone, an organic molecule, without the aid of any metallic catalysts or reagents.
通过苯甲酮介导的饱和杂环与磺酰嘧啶之间的光诱导偶联，实现了烷基嘧啶的合成。嘧啶环被选择性地引入到包括氧、氮和硫在内的杂原子附近的非酸性 C(sp)-H 键上。这是一种仅由光激发的苯甲酮介导的偶联反应，不需要任何金属催化剂或试剂。
