使用氯化亚砜将叔丁酯转化为酰氯。
The Conversion of tert-Butyl Esters to Acid Chlorides Using Thionyl Chloride.
机构信息
Department of Chemistry and Biochemistry, University of Colorado Boulder , Boulder, Colorado 80309, United States.
出版信息
J Org Chem. 2017 Mar 17;82(6):3245-3251. doi: 10.1021/acs.joc.6b02931. Epub 2017 Feb 27.
PMID:28195740
Abstract
The reaction of tert-butyl esters with SOCl at room temperature provides acid chlorides in unpurified yields of 89% or greater. Benzyl, methyl, ethyl, and isopropyl esters are essentially unreactive under these conditions, allowing for the selective conversion of tert-butyl esters to acid chlorides in the presence of other esters.
摘要
叔丁酯与 SOCl 在室温下反应，以未经纯化的 89%或更高的收率提供酰氯。在这些条件下，苄基、甲基、乙基和异丙基酯基本上没有反应性，因此可以在存在其他酯的情况下选择性地将叔丁酯转化为酰氯。
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