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锶取代骨水泥引导间充质干细胞、成骨细胞和破骨细胞的命运。

Sr-substituted bone cements direct mesenchymal stem cells, osteoblasts and osteoclasts fate.

作者信息

Montesi Monica, Panseri Silvia, Dapporto Massimiliano, Tampieri Anna, Sprio Simone

机构信息

Institute of Science and Technology for Ceramics, National Research Council, Faenza, Ravenna, Italy.

出版信息

PLoS One. 2017 Feb 14;12(2):e0172100. doi: 10.1371/journal.pone.0172100. eCollection 2017.

Abstract

Strontium-substituted apatitic bone cements enriched with sodium alginate were developed as a potential modulator of bone cells fate. The biological impact of the bone cement were investigated in vitro through the study of the effect of the nanostructured apatitic composition and the doping of strontium on mesenchymal stem cells, pre-osteoblasts and osteoclasts behaviours. Up to 14 days of culture the bone cells viability, proliferation, morphology and gene expression profiles were evaluated. The results showed that different concentrations of strontium were able to evoke a cell-specific response, in fact an inductive effect on mesenchymal stem cells differentiation and pre-osteoblasts proliferation and an inhibitory effect on osteoclasts activity were observed. Moreover, the apatitic structure of the cements provided a biomimetic environment suitable for bone cells growth. Therefore, the combination of biological features of this bone cement makes it as promising biomaterials for tissue regeneration.

摘要

富含海藻酸钠的锶取代磷灰石骨水泥被开发为一种潜在的骨细胞命运调节剂。通过研究纳米结构磷灰石组成和锶掺杂对间充质干细胞、前成骨细胞和破骨细胞行为的影响,在体外研究了骨水泥的生物学影响。在长达14天的培养过程中,评估了骨细胞的活力、增殖、形态和基因表达谱。结果表明,不同浓度的锶能够引发细胞特异性反应,事实上,观察到对间充质干细胞分化和前成骨细胞增殖有诱导作用,对破骨细胞活性有抑制作用。此外,骨水泥的磷灰石结构提供了适合骨细胞生长的仿生环境。因此,这种骨水泥的生物学特性使其成为用于组织再生的有前景的生物材料。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1318/5308610/f22419fa87e3/pone.0172100.g001.jpg

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