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主动脉内球囊反搏对接受直接经皮冠状动脉介入治疗的心源性休克患者是否足够有效?

Is Intra-Aortic Balloon Pump Counterpulsation Sufficient to Treat Patients in Cardiogenic Shock, Undergoing Primary Percutaneous Coronary Intervention.

作者信息

Paton Maria, Ashton Lisa, Pearson Ian, Sivananthan Mohan

机构信息

University of Leeds, Leeds, UK.

Leeds Heart Centre, Leeds, UK.

出版信息

Cardiol Res. 2015 Dec;6(6):339-345. doi: 10.14740/cr415w. Epub 2015 Dec 16.

Abstract

BACKGROUND

A high number of patients do not survive primary percutaneous coronary intervention (PCI) complicated by cardiogenic shock (CS), even when assisted with intra-aortic balloon pump (IABP) counterpulsation. There is no accepted consensus on who may most benefit from IABP counterpulsation, although previous retrospective studies have reported predictors of survival for patients undergoing PCI and cardiac surgery. To date, a risk model for emergency primary PCI patients has not been ascertained. The objective of this study was to identify independent predictors for in-hospital survival, to create a standardized risk model to predict patients who may require IABP insertion during primary PCI.

METHOD

Retrospective data were from 165 patients who had undergone primary PCI with IABP due to CS complicating acute myocardial infarction (AMI), from September 2007 to 2010, and underwent logistic regression analysis, to evaluate the incremental risk factors associated with survival.

RESULTS

The overall in-hospital mortality was 32.1% (53 patients). The incremental independent predictors for in-hospital survival were: patient age of less than 60 years (OR: 0.303, 95% CI: 0.11 - 0.83, P < 0.02) and the use of IABP support alone, as opposed to in adjunction with inotropic support (OR: 3.177, 95% CI: 1.159 - 8.708, P < 0.025).

CONCLUSION

This study illustrated an age of less than 60 years, and the use of IABP alone, to be independent predictors of in-hospital survival in patients with CS complicating AMI who undergo primary PCI assisted by IABP. No specific risk model could be determined.

摘要

背景

大量因心源性休克(CS)并发接受直接经皮冠状动脉介入治疗(PCI)的患者即便接受主动脉内球囊反搏(IABP)辅助也未能存活。尽管既往回顾性研究报道了接受PCI和心脏手术患者的生存预测因素,但对于谁最能从IABP反搏中获益尚无公认的共识。迄今为止,尚未确定急诊直接PCI患者的风险模型。本研究的目的是确定院内生存的独立预测因素,创建一个标准化风险模型以预测在直接PCI期间可能需要插入IABP的患者。

方法

回顾性分析2007年9月至2010年期间因CS并发急性心肌梗死(AMI)接受IABP辅助直接PCI的165例患者的数据,并进行逻辑回归分析,以评估与生存相关的增量风险因素。

结果

院内总死亡率为32.1%(53例患者)。院内生存的增量独立预测因素为:年龄小于60岁(OR:0.303,95%CI:0.11 - 0.83,P < 0.02)以及单独使用IABP支持,而非与血管活性药物支持联合使用(OR:3.177,95%CI:1.159 - 8.708,P < 0.025)。

结论

本研究表明,年龄小于60岁以及单独使用IABP是因CS并发AMI接受IABP辅助直接PCI患者院内生存的独立预测因素。无法确定特定的风险模型。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6607/5295547/bca792b07833/cr-06-339-g001.jpg

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