Haenzi Barbara, Moon Lawrence D F
Neurorestoration Group, Wolfson Centre for Age-Related Diseases, King's College London, London SE1 1UL, UK.
Neural Plast. 2017;2017:2740768. doi: 10.1155/2017/2740768. Epub 2017 Jan 18.
Extensive research is ongoing that concentrates on finding therapies to enhance CNS regeneration after spinal cord injury (SCI) and to cure paralysis. This review sheds light on the role of the FGFR pathway in the injured spinal cord and discusses various therapies that use FGFR activating ligands to promote regeneration after SCI. We discuss studies that use peripheral nerve grafts or Schwann cell grafts in combination with FGF1 or FGF2 supplementation. Most of these studies show evidence that these therapies successfully enhance axon regeneration into the graft. Further they provide evidence for partial recovery of sensory function shown by electrophysiology and motor activity evidenced by behavioural data. We also present one study that indicates that combination with additional, synergistic factors might further drive the system towards functional regeneration. In essence, this review summarises the potential of nerve and cell grafts combined with FGF1/2 supplementation to improve outcome even after severe spinal cord injury.
目前正在进行广泛的研究，重点是寻找促进脊髓损伤（SCI）后中枢神经系统再生和治愈瘫痪的疗法。本综述阐明了FGFR通路在脊髓损伤中的作用，并讨论了各种使用FGFR激活配体促进SCI后再生的疗法。我们讨论了将周围神经移植或雪旺细胞移植与补充FGF1或FGF2相结合的研究。这些研究大多表明，这些疗法成功地促进了轴突向移植物中的再生。此外，它们还为电生理学显示的感觉功能部分恢复以及行为数据证明的运动活动提供了证据。我们还介绍了一项研究，该研究表明与其他协同因子联合使用可能会进一步推动该系统实现功能再生。本质上，本综述总结了神经和细胞移植结合补充FGF1/2改善严重脊髓损伤后预后的潜力。
