Department of Anatomy, Histology and Embryology, Institute of Neuroanatomy, Medical University of Innsbruck, Innsbruck, Austria.
Institute of Neuroanatomy and Cell Biology, Hannover Medical School, Hannover, Germany.
Mol Neurobiol. 2021 Aug;58(8):3884-3902. doi: 10.1007/s12035-021-02367-0. Epub 2021 Apr 15.
Fibroblast growth factors (FGFs) act as key signalling molecules in brain development, maintenance, and repair. They influence the intricate relationship between myelinating cells and axons as well as the association of astrocytic and microglial processes with neuronal perikarya and synapses. Advances in molecular genetics and imaging techniques have allowed novel insights into FGF signalling in recent years. Conditional mouse mutants have revealed the functional significance of neuronal and glial FGF receptors, not only in tissue protection, axon regeneration, and glial proliferation but also in instant behavioural changes. This review provides a summary of recent findings regarding the role of FGFs and their receptors in the nervous system and in the pathogenesis of major neurological and psychiatric disorders.
成纤维细胞生长因子（FGFs）在大脑发育、维持和修复中作为关键信号分子发挥作用。它们影响髓鞘细胞和轴突之间的复杂关系，以及星形胶质细胞和小胶质细胞过程与神经元胞体和突触的关联。近年来，分子遗传学和成像技术的进步使人们对 FGF 信号有了新的认识。条件性小鼠突变体揭示了神经元和神经胶质 FGF 受体的功能意义，不仅在组织保护、轴突再生和神经胶质增殖方面，而且在即时的行为变化方面。这篇综述总结了最近关于 FGF 及其受体在神经系统以及主要神经和精神疾病发病机制中的作用的发现。
