Binnebösel M, Lambertz A, Klink C D, Neumann U P
Klinik für Allgemein-, Viszeral und Transplantationschirurgie, Uniklinik der RWTH Aachen, Pauwelsstr. 30, 52074, Aachen, Deutschland.
Urologe A. 2017 Mar;56(3):313-321. doi: 10.1007/s00120-017-0334-3.
Radiotherapy in the treatment of prostate cancer is well established. Intestinal complications following radiotherapy are divided into acute and chronic toxicity. Chronic complications like perforation and fistula formation to the rectum are rare and difficult to treat.
In case of chronic radiotherapy complications and particularly chronic fistula formation to the rectum, evidence is low. Therefore, an overview of the available literature of surgical therapy strategies is given.
Options for the treatment of acute intestinal toxicity are established and therapy algorithms exist. Therapy of acute rectal perforation covers primary suture repair with or without diversion stoma as well as primary rectal resection with or without primary restoring bowel continuity. In chronic rectal lesions and particularly in fistula formation to the rectum, abdominal treatment strategies are preferred with additional interposition of an omental flap or vascularized muscle flap.
Although evidence for surgical therapy strategies of the rare chronic rectourethral and rectovesical fistula is low, treatment is a real interdisciplinary challenge and should be provided in a specialized center.
放疗在前列腺癌的治疗中已得到广泛应用。放疗后的肠道并发症分为急性和慢性毒性反应。像直肠穿孔和直肠瘘形成这样的慢性并发症较为罕见且难以治疗。
对于慢性放疗并发症,尤其是直肠慢性瘘形成,相关证据较少。因此,本文对现有的手术治疗策略文献进行了综述。
急性肠道毒性的治疗方法已经确立,并且存在治疗算法。急性直肠穿孔的治疗包括带或不带转流造口的一期缝合修复以及带或不带一期肠道连续性恢复的直肠切除术。对于慢性直肠病变,尤其是直肠瘘形成,首选腹部治疗策略,并附加网膜瓣或带血管肌瓣的置入。
尽管对于罕见的慢性直肠尿道瘘和直肠膀胱瘘的手术治疗策略证据较少,但治疗是一项真正的跨学科挑战,应在专业中心进行。