有丝分裂中的类泛素化修饰途径
The SUMO Pathway in Mitosis.
作者信息
Mukhopadhyay Debaditya, Dasso Mary
机构信息
Section on Cell Cycle Regulation, Laboratory of Gene Regulation and Development, National Institute of Child Health and Development, National Institutes of Health, 18 Library Drive, Room 106, Building 18T, Bethesda, MD, 20892, USA.
出版信息
Adv Exp Med Biol. 2017;963:171-184. doi: 10.1007/978-3-319-50044-7_10.
Abstract
Mitosis is the stage of the cell cycle during which replicated chromosomes must be precisely divided to allow the formation of two daughter cells possessing equal genetic material. Much of the careful spatial and temporal organization of mitosis is maintained through post-translational modifications, such as phosphorylation and ubiquitination, of key cellular proteins. Here, we will review evidence that sumoylation, conjugation to the SUMO family of small ubiquitin-like modifiers, also serves essential regulatory roles during mitosis. We will discuss the basic biology of sumoylation, how the SUMO pathway has been implicated in particular mitotic functions, including chromosome condensation, centromere/kinetochore organization and cytokinesis, and what cellular proteins may be the targets underlying these phenomena.
摘要
有丝分裂是细胞周期中的一个阶段，在此期间，复制后的染色体必须精确分离，以便形成两个拥有相等遗传物质的子细胞。有丝分裂过程中许多精细的时空组织是通过关键细胞蛋白的翻译后修饰（如磷酸化和泛素化）来维持的。在这里，我们将综述证据表明，小泛素样修饰物SUMO家族的缀合反应——SUMO化，在有丝分裂过程中也起着重要的调节作用。我们将讨论SUMO化的基本生物学特性，SUMO途径如何参与特定的有丝分裂功能，包括染色体浓缩、着丝粒/动粒组织和胞质分裂，以及哪些细胞蛋白可能是这些现象背后的靶点。
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