依那普利成功治疗硬皮病肾危象。
Successful treatment of scleroderma renal crisis with enalapril.
作者信息
Milsom S R, Nicholls M G
出版信息
Postgrad Med J. 1986 Nov;62(733):1059-60. doi: 10.1136/pgmj.62.733.1059.
Abstract
A patient with scleroderma renal crisis is described. At presentation he had severe hypertension, deteriorating renal function, microangiopathic haemolytic anaemia, and elevated levels of renin, aldosterone and noradrenaline. Enalapril controlled blood pressure, stabilized renal function, lowered aldosterone and noradrenaline levels, and improved peripheral circulation. It appears that converting-enzyme inhibitors can favourably alter the outlook of this otherwise fatal disorder.
摘要
本文描述了一名患有硬皮病肾危象的患者。初诊时，他患有严重高血压、肾功能恶化、微血管病性溶血性贫血，肾素、醛固酮和去甲肾上腺素水平升高。依那普利控制了血压，稳定了肾功能，降低了醛固酮和去甲肾上腺素水平，并改善了外周循环。看来，转换酶抑制剂可以有利地改变这种原本致命疾病的预后。
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本文引用的文献
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Medical treatment of hypertension and renal failure in scleroderma.硬皮病中高血压和肾衰竭的医学治疗
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Captopril in the treatment of scleroderma renal crisis.卡托普利治疗硬皮病肾危象
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Hypertension and renal failure (scleroderma renal crisis) in progressive systemic sclerosis. Review of a 25-year experience with 68 cases.进行性系统性硬化症中的高血压与肾衰竭（硬皮病肾危象）。25年68例病例回顾。
Medicine (Baltimore). 1983 Nov;62(6):335-52. doi: 10.1097/00005792-198311000-00001.
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Hypertensive crisis in systemic sclerosis: treatment with the new oral angiotensin converting enzyme inhibitor MK, 421 (Enalapril) in captopril-intolerant patients.
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Reversal of vascular and renal crises of scleroderma by oral angiotensin-converting-enzyme blockade.口服血管紧张素转换酶抑制剂逆转硬皮病的血管和肾脏危象
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