Giralt M, Garcia-Marquez C, Armario A
Physiol Behav. 1987;40(2):165-70. doi: 10.1016/0031-9384(87)90202-2.
The effect of previous chronic ACTH administration on the physiological response to acute and chronic immobilization stress was studied in adult male rats. Chronic ACTH administration slightly reduced food intake and drastically inhibited body weight gain. Serum corticosterone levels were similar in saline- and ACTH-treated rats twenty hours after the last administration. However, the corticosterone response to 1 hr immobilization was greatly reduced by previous ACTH administration. When the exposure to the stressor was prolonged up to 18 hours, the corticosterone response was similar in saline, and ACTH-treated rats. While body weight loss caused by starvation and acute stress was lower in ACTH-treated rats, stomach ulceration was greater in the latter animals. Although ACTH-treated rats showed higher body weight gain than saline-treated animals during chronic immobilization, this was probably due to catch-up growth as food intake inhibition caused by the stressor was similar in the two groups. Pituitary-adrenal adaptation to the repeated stressor was the same in saline- and ACTH-treated rats. Therefore, the effects of previous ACTH treated on the physiological response to either acute or chronic stress appear to be mixed, depending on the variable studied.
在成年雄性大鼠中研究了先前长期给予促肾上腺皮质激素（ACTH）对急性和慢性固定应激生理反应的影响。长期给予ACTH会使食物摄入量略有减少，并显著抑制体重增加。在最后一次给药20小时后，生理盐水处理组和ACTH处理组大鼠的血清皮质酮水平相似。然而，先前给予ACTH会使皮质酮对1小时固定应激的反应大大降低。当应激源暴露延长至18小时时，生理盐水处理组和ACTH处理组大鼠的皮质酮反应相似。虽然饥饿和急性应激导致的ACTH处理组大鼠体重减轻较少，但后者动物的胃溃疡更严重。虽然在慢性固定期间，ACTH处理组大鼠的体重增加高于生理盐水处理组动物，但这可能是由于追赶生长，因为应激源引起的食物摄入抑制在两组中相似。生理盐水处理组和ACTH处理组大鼠垂体-肾上腺对重复应激源的适应性相同。因此，先前ACTH处理对急性或慢性应激生理反应的影响似乎是混合的，这取决于所研究的变量。
