Flores S C, Moore T K, Gaubatz J W
Plasmid. 1987 May;17(3):257-60. doi: 10.1016/0147-619x(87)90034-5.
Eukaryotic cells contain extrachromosomal circular (ecc) DNAs which are homologous to chromosomal sequences. We have isolated eccDNAs from whole tissues of C57BL/6 mice. Using hybridization techniques, we show that R-, MIF-, B1-, and B2-dispersed repetitive sequences of the mouse genome are differentially represented in heart, brain, and liver tissues. Moreover, we show that the relative abundance of B2 sequences in heart and liver eccDNAs is higher than the relative abundance of the other repetitive sequence families studied.
真核细胞含有与染色体序列同源的染色体外环状（ecc）DNA。我们从C57BL/6小鼠的全组织中分离出了eccDNA。利用杂交技术，我们发现小鼠基因组的R、MIF、B1和B2分散重复序列在心脏、大脑和肝脏组织中的表达存在差异。此外，我们还发现心脏和肝脏eccDNA中B2序列的相对丰度高于所研究的其他重复序列家族的相对丰度。
