G重复序列：一种新型仓鼠正弦家族。
G-repeats: a novel hamster sine family.
作者信息
Miles C, Meuth M
机构信息
Imperial Cancer Research Fund, Clare Hall Laboratories, Herts, UK.
出版信息
Nucleic Acids Res. 1989 Sep 25;17(18):7221-8. doi: 10.1093/nar/17.18.7221.
A fragment of a hamster repetitive element inserted into the aprt locus of a radiation-induced mutant is a member of a novel interspersed repetitive (SINE) family constituting approximately 0.3 to 0.5% of the hamster genome (30 to 50,000 family members). Since this family was first detected in a gene rearranged after exposure to gamma irradiation, we have called these G-repeats. In common with other repetitive elements, members of this family are about 300 bp in length, are highly divergent (an average of 30% from the consensus), have an A + T rich sequence flanking one side, and can be found in short polydisperse circular (SPC) DNA. In contrast to some other families, G-repeats are not flanked by short direct repeats and lack sequences corresponding to the RNA polymerase III consensus promoter.
插入到辐射诱导突变体aprt基因座中的一段仓鼠重复元件是一个新的散布重复（SINE）家族的成员，该家族约占仓鼠基因组的0.3%至0.5%（30,000至50,000个家族成员）。由于这个家族最初是在暴露于γ射线照射后发生基因重排时被检测到的，我们将这些称为G重复序列。与其他重复元件一样，这个家族的成员长度约为300 bp，高度发散（与共有序列平均有30%的差异），一侧有富含A + T的序列，并且可以在短的多分散环状（SPC）DNA中找到。与其他一些家族不同，G重复序列两侧没有短的直接重复序列，并且缺乏与RNA聚合酶III共有启动子相对应的序列。
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