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Modulatory effect of alpha 2 adrenoceptor agonists on Ro 5-4864-induced convulsions in rats and mice.

作者信息

Kunchandy J, Kulkarni S K

出版信息

Psychopharmacology (Berl). 1987;93(1):113-7. doi: 10.1007/BF02439596.

DOI:10.1007/BF02439596
PMID:2819922
Abstract

The protective effect of various alpha 2 adrenoceptor agonists such as clonidine, guanfacine, B-HT 920 and ICI 106270 was investigated against Ro 5-4864-induced convulsions in mice and rats. Clonidine and ICI 106270 exhibited a profound anticonvulsant effect while equivalent doses of guanfacine and B-HT 920 were less effective. The anticonvulsant effect of clonidine and ICI 106270 was reversed by pretreatment with yohimbine or idazoxan, indicating the involvement of alpha 2 adrenoceptors in their protective effect. Diazepam, clonazepam, CL 218, 872 and pentobarbitone exhibited a different profile of protective action, as these agents protected the animals from apparent mortality as compared to clonidine and ICI 106270 which prolonged the latencies of jerk and convulsion. Modulatory effects of alpha 2 adrenoceptors in central GABA function and multiple sites for Ro 5-4864-induced seizures are explained.

摘要

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本文引用的文献

1
Actions of clonidine on convulsions and behaviour.可乐定对惊厥和行为的作用。
Arch Int Pharmacodyn Ther. 1981 Jul;252(1):124-32.
2
Sedative and anticonvulsant effects of adenosine analogs in mouse and rat.腺苷类似物对小鼠和大鼠的镇静及抗惊厥作用
J Pharmacol Exp Ther. 1982 Jan;220(1):70-6.
3
Ro 5-4864: a potent benzodiazepine convulsant.
Eur J Pharmacol. 1983 May 20;90(1):149-50. doi: 10.1016/0014-2999(83)90229-7.
4
Modification by GABA-ergic agents and clonidine of morphine-induced convulsions and toxicity in rats.
Clin Exp Pharmacol Physiol. 1983 Mar-Apr;10(2):125-9. doi: 10.1111/j.1440-1681.1983.tb00178.x.
5
The anxiogenic action of Ro 5-4864 is reversed by phenytoin.苯妥英可逆转Ro 5-4864的致焦虑作用。
Neurosci Lett. 1983 Jan 31;35(1):93-6. doi: 10.1016/0304-3940(83)90532-3.
6
RO5-4864 inhibits the binding of [35S]t-butylbicyclophosphorothionate to rat brain membranes.
Life Sci. 1984 Feb 13;34(7):631-8. doi: 10.1016/0024-3205(84)90226-1.
7
Possible mechanism of digoxin-induced convulsions.
Psychopharmacology (Berl). 1983;79(2-3):287-9. doi: 10.1007/BF00427829.
8
On the convulsant action of Ro 5-4864 and the existence of a micromolar benzodiazepine binding site in rat brain.关于Ro 5-4864的惊厥作用以及大鼠脑中微摩尔级苯二氮䓬结合位点的存在
Psychopharmacology (Berl). 1984;82(3):199-202. doi: 10.1007/BF00427773.
9
Characterization of the alpha adrenoceptor-mediated effects and antihypertensive activity of ICI 106270: comparison with clonidine.
J Pharmacol Exp Ther. 1984 Apr;229(1):58-66.
10
Electrophysiological and pharmacological actions of the convulsant benzodiazepine Ro 5-4864.
Eur J Pharmacol. 1984 Jan 27;97(3-4):257-63. doi: 10.1016/0014-2999(84)90457-6.

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