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Ro 5-4864: a potent benzodiazepine convulsant.

作者信息

Weissman B A, Cott J, Paul S M, Skolnick P

出版信息

Eur J Pharmacol. 1983 May 20;90(1):149-50. doi: 10.1016/0014-2999(83)90229-7.

DOI:10.1016/0014-2999(83)90229-7
PMID:6873175
Abstract
摘要

相似文献

1
Ro 5-4864: a potent benzodiazepine convulsant.
Eur J Pharmacol. 1983 May 20;90(1):149-50. doi: 10.1016/0014-2999(83)90229-7.
2
Reduction of gamma-aminobutyric acid (GABA)-mediated transmission by a convulsant benzodiazepine.一种惊厥性苯二氮䓬类药物对γ-氨基丁酸（GABA）介导的神经传递的抑制作用。
J Pharmacol Exp Ther. 1979 Nov;211(2):290-5.
3
Pharmacological, electrophysiological, and neurochemical actions of the convulsant benzodiazepine Ro 5-4864 (4'-chlordiazepam).惊厥性苯二氮䓬类药物Ro 5-4864（4'-氯地西泮）的药理、电生理及神经化学作用
Adv Biochem Psychopharmacol. 1983;38:139-51.
4
Pro- and anti-convulsant properties of PK 11195, a ligand for benzodiazepine binding sites: development of tolerance.苯二氮䓬结合位点配体PK 11195的促惊厥和抗惊厥特性：耐受性的发展
Br J Pharmacol. 1984 Oct;83(2):471-6. doi: 10.1111/j.1476-5381.1984.tb16509.x.
5
Convulsant benzodiazepine Ro 5-3663 has anxiolytic properties.惊厥性苯二氮䓬类药物Ro 5-3663具有抗焦虑特性。
Pharmacol Biochem Behav. 1982 May;16(5):689-91. doi: 10.1016/0091-3057(82)90218-0.
6
Convulsant action of a benzodiazepine Ro 16-6028 during ontogenesis in rats.苯二氮䓬Ro 16-6028在大鼠个体发育过程中的惊厥作用。
Homeost Health Dis. 1991;33(4):180.
7
Differential regulation of 'central' and 'peripheral' benzodiazepine binding sites in the rat olfactory bulb.大鼠嗅球中“中枢性”和“外周性”苯二氮䓬结合位点的差异调节
Eur J Pharmacol. 1984 Oct 1;105(1-2):143-8. doi: 10.1016/0014-2999(84)90658-7.
8
Interactions of the imidazodiazepine Ro 15-4513 with chemical convulsants.咪唑二氮䓬Ro 15-4513与化学惊厥剂的相互作用。
Br J Pharmacol. 1988 Jan;93(1):210-4. doi: 10.1111/j.1476-5381.1988.tb11423.x.
9
Are "peripheral-type" binding sites for benzodiazepines in brain related to the convulsant actions of Ro 5-4864?脑中苯二氮䓬类药物的“外周型”结合位点与Ro 5-4864的惊厥作用有关吗？
Prog Clin Biol Res. 1985;192:197-203.
10
Electrophysiological and pharmacological actions of the convulsant benzodiazepine Ro 5-4864.
Eur J Pharmacol. 1984 Jan 27;97(3-4):257-63. doi: 10.1016/0014-2999(84)90457-6.

引用本文的文献

1
2-Phenyl-imidazo[1,2-a]pyridine derivatives as ligands for peripheral benzodiazepine receptors: stimulation of neurosteroid synthesis and anticonflict action in rats.2-苯基-咪唑并[1,2-a]吡啶衍生物作为外周苯二氮䓬受体的配体：对大鼠神经甾体合成的刺激作用及抗冲突作用
Br J Pharmacol. 1999 May;127(1):177-87. doi: 10.1038/sj.bjp.0702530.
2
On the convulsant action of Ro 5-4864 and the existence of a micromolar benzodiazepine binding site in rat brain.关于Ro 5-4864的惊厥作用以及大鼠脑中微摩尔级苯二氮䓬结合位点的存在
Psychopharmacology (Berl). 1984;82(3):199-202. doi: 10.1007/BF00427773.
3
Multiple sites of action for anxiogenic drugs: behavioural, electrophysiological and biochemical correlations.
抗焦虑药物的多个作用位点：行为、电生理及生化相关性
Psychopharmacology (Berl). 1984;83(4):304-15. doi: 10.1007/BF00428536.
4
The peripheral benzodiazepine receptor ligand Ro 5-4864 induces supraspinal convulsions in rabbits. Reversal by the central benzodiazepine antagonist Ro 15-1788.外周苯二氮䓬受体配体Ro 5-4864可诱发家兔脊髓上惊厥。可被中枢苯二氮䓬拮抗剂Ro 15-1788逆转。
Psychopharmacology (Berl). 1986;88(3):336-40. doi: 10.1007/BF00180835.
5
Autoradiographic localization of "peripheral-type" benzodiazepine binding sites in the rat brain, heart and kidney.大鼠脑、心脏和肾脏中“外周型”苯二氮䓬结合位点的放射自显影定位
Naunyn Schmiedebergs Arch Pharmacol. 1985 Feb;328(4):454-60. doi: 10.1007/BF00692915.
6
Blockade of non-opioid analgesia in intruder mice by selective neuronal and non-neuronal benzodiazepine recognition site ligands.通过选择性神经元和非神经元苯二氮䓬识别位点配体对入侵小鼠非阿片类镇痛的阻断作用。
Psychopharmacology (Berl). 1988;96(1):45-54. doi: 10.1007/BF02431532.
7
Modulatory effect of alpha 2 adrenoceptor agonists on Ro 5-4864-induced convulsions in rats and mice.
Psychopharmacology (Berl). 1987;93(1):113-7. doi: 10.1007/BF02439596.
8
Mitochondrial benzodiazepine receptors regulate steroid biosynthesis.线粒体苯二氮䓬受体调节类固醇生物合成。
Proc Natl Acad Sci U S A. 1989 Dec;86(24):9813-6. doi: 10.1073/pnas.86.24.9813.
9
Differential effects of anxiogenic central and peripheral benzodiazepine receptor ligands in tests of learning and memory.致焦虑的中枢和外周苯二氮䓬受体配体在学习和记忆测试中的差异效应。
Psychopharmacology (Berl). 1991;104(2):249-54. doi: 10.1007/BF02244187.