Lee Sang Min, Jang Kuk-In, Chae Jeong-Ho
1 Department of Biomedicine & Health Sciences, The Catholic University of Korea, College of Medicine, Seoul, Korea.
2 Department of Psychiatry, Seoul St. Mary's Hospital, The Catholic University of Korea, College of Medicine, Seoul, Korea.
Clin EEG Neurosci. 2017 Sep;48(5):316-321. doi: 10.1177/1550059417692083. Epub 2017 Feb 15.
Previous studies have indicated that the abnormalities of brain activity are associated with suicidal behavior. However, few studies have explored neurophysiologic biomarkers of suicidal ideation (SI) in healthy subjects. Here, we studied alterations of theta quantitative EEG (QEEG) in frontal regions associated with SI in young healthy subjects. Resting QEEG data were recorded from 90 young healthy subjects. The subjects were divided into two group based on Scale for Suicidal Ideation (SSI) scores: a high SSI group (n = 33) and a low SSI group (n = 57). Individual frontal electrodes (Fp1, Fp2, F7, F3, Fz, F4, F8) and central midline electrodes (FCz, Cz) were examined for absolute and relative power in the theta band. Clinical state and social support was assessed using the Hospital Anxiety and Depression Scale and Functional Social Support Questionnaire. We found that theta absolute and relative power in all channels was positively correlated with SSI, except Fp1, F7 and F8. The high SSI group showed higher theta relative power at F3, Fz, FCz, and Cz than the low SSI group. Theta relative power in the fronto-central region was significantly increased in the high SSI group compared to that in the low SSI group. Hierarchical regression analysis showed that SSI score was the most powerful predictor of fronto-central theta power. The findings suggest that brain electrical activity at the fronto-central region may be associated with differences in SI in young healthy subjects. EEG activity in theta band has clinical potential as a biomarker for preventing suicide.
先前的研究表明，大脑活动异常与自杀行为有关。然而，很少有研究探索健康受试者中自杀意念（SI）的神经生理学生物标志物。在此，我们研究了年轻健康受试者中与SI相关的额叶区域θ定量脑电图（QEEG）的变化。记录了90名年轻健康受试者的静息QEEG数据。根据自杀意念量表（SSI）得分将受试者分为两组：高SSI组（n = 33）和低SSI组（n = 57）。检查了各个额叶电极（Fp1、Fp2、F7、F3、Fz、F4、F8）和中央中线电极（FCz、Cz）在θ波段的绝对功率和相对功率。使用医院焦虑抑郁量表和功能性社会支持问卷评估临床状态和社会支持。我们发现，除Fp1、F7和F8外，所有通道的θ绝对功率和相对功率均与SSI呈正相关。高SSI组在F3、Fz、FCz和Cz处的θ相对功率高于低SSI组。与低SSI组相比，高SSI组额中央区域的θ相对功率显著增加。分层回归分析表明，SSI得分是额中央θ功率最有力的预测指标。这些发现表明，年轻健康受试者额中央区域的脑电活动可能与SI的差异有关。θ波段的脑电图活动作为预防自杀的生物标志物具有临床潜力。
