Department of Psychiatry and Psychology, Mayo Clinic, Rochester, Minnesota, USA.
Department of Psychiatry, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.
J Child Adolesc Psychopharmacol. 2023 Sep;33(7):287-293. doi: 10.1089/cap.2023.0033. Epub 2023 Sep 5.
Major depressive disorder (MDD) is a primary risk factor for suicide, which is one of the leading causes of death among adolescents worldwide. Understanding the heterogeneity of suicidality in adolescents with MDD is critical for suicide prevention and intervention discovery. Quantitative electroencephalography (EEG) is a promising tool to address the knowledge gaps related to the neurophysiological characteristics of depression and suicidality. This study sought to examine resting-state EEG coherence differences in adolescents with MDD and suicidal ideation (SI)/behaviors (SB) and healthy controls (HC) to assess the utility of coherence as a biomarker of suicide. Twenty-six adolescents with MDD who were hospitalized for suicidality and 30 HC were recruited. The clinical sample was divided into SI ( = 9) and SB ( = 19) subgroups. Eyes closed resting-state EEG were recorded, and coherence was calculated. Depression severity and suicidality were assessed with the Children's Depression Rating Scale Revised and the Columbia Suicide Severity Rating Scale, respectively. There were intrahemispheric differences in the right hemisphere across multiple electrode pairs. Delta, alpha, and beta coherence were higher in the SB group over the right prefrontofrontal and left parietooccipital electrode pairs, while alpha coherence was higher in the HC group over the right centroparietal electrode pair. There were no significant differences between HC and SI groups in any electrode pair. Patients with recent SB showed increased coherence in right frontal regions compared with patients with SI, suggesting altered cognitive states between those with SB and SI. These findings may have implications for suicide prevention in adolescents and could serve as useful biomarkers in clinical settings, but larger studies are needed to confirm the results.
重性抑郁障碍（MDD）是自杀的主要危险因素之一，自杀也是全球青少年死亡的主要原因之一。了解 MDD 青少年自杀意念（SI）/行为（SB）的异质性对于预防自杀和发现干预措施至关重要。定量脑电图（EEG）是一种很有前途的工具，可以解决与抑郁和自杀的神经生理特征相关的知识空白。本研究旨在检查 MDD 伴 SI/SB 青少年与健康对照者（HC）静息状态 EEG 相干性差异，以评估相干性作为自杀生物标志物的效用。 共招募了 26 名因自杀而住院的 MDD 青少年和 30 名 HC。临床样本分为 SI（ = 9）和 SB（ = 19）亚组。记录闭眼静息状态 EEG，并计算相干性。使用儿童抑郁评定量表修订版和哥伦比亚自杀严重程度评定量表评估抑郁严重程度和自杀意念。 在多个电极对上，右侧半球存在半球内差异。SB 组的右额额和左顶枕电极对上的 delta、alpha 和 beta 相干性较高，而 HC 组的右中央顶电极对上的 alpha 相干性较高。在任何电极对上，HC 和 SI 组之间均无显着差异。 与有 SI 的患者相比，近期有 SB 的患者右侧额区的相干性增加，这表明 SB 和 SI 患者之间的认知状态发生了改变。这些发现可能对青少年的自杀预防具有重要意义，并可能成为临床实践中的有用生物标志物，但需要更大规模的研究来证实这些结果。
