引流液中可溶性细胞间黏附分子-1水平与腹膜透析中腹膜损伤的关系。

The association between soluble intercellular adhesion molecule-1 levels in drained dialysate and peritoneal injury in peritoneal dialysis.

作者信息

Igarashi Yusuke, Morishita Yoshiyuki, Yoshizawa Hiromichi, Imai Reika, Imai Toshimi, Hirahara Ichiro, Akimoto Tetsu, Ookawara Susumu, Ishibashi Kenichi, Muto Shigeaki, Nagata Daisuke

机构信息

a Division of Nephrology, Department of Internal Medicine , Jichi Medical University , Shimotsuke City , Tochigi , Japan.

b Division of Nephrology, Department of Integrated Medicine , Saitama Medical Center, Jichi Medical University , Omiya, Saitama City, Saitama , Japan.

出版信息

Ren Fail. 2017 Nov;39(1):392-399. doi: 10.1080/0886022X.2017.1287735.

DOI:10.1080/0886022X.2017.1287735

PMID:28201944

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6014485/

Abstract

BACKGROUND

Chronic inflammation of the peritoneum causes peritoneal injury in patients on peritoneal dialysis. Intercellular adhesion molecule-1 and its circulating form, soluble intercellular adhesion molecule-1, play pivotal roles in inflammation. However, their role in peritoneal injury is unclear.

METHODS

We measured changes in intercellular adhesion molecule-1 expression in the peritoneum of a peritoneal injury model in rats. The associations between soluble intercellular adhesion molecule-1 levels in drained dialysate and the solute transport rate (D/P-Cr and D/D0-glucose) determined by the peritoneal equilibration test, and matrix metalloproteinase-2 levels in drained dialysate were investigated in 94 peritoneal drained dialysate samples.

RESULTS

Intercellular adhesion molecule-1 expression was increased in the peritoneum of rats with peritoneal injury. Soluble intercellular adhesion molecule-1 levels in drained dialysate were significantly positively correlated with D/P-Cr (r = .51, p < .01) and inversely correlated with D/D0-glucose (r = -.44, p < .01). They were also significantly positively correlated with matrix metalloproteinase-2 levels in drained dialysate (r = .86, p < .01).

CONCLUSIONS

Intercellular adhesion molecule-1expression is increased in the peritoneum of a peritoneal injury model in the rat, and soluble intercellular adhesion molecule-1 levels in drained dialysate are associated with peritoneal injury in patients on peritoneal dialysis. These results suggest that soluble intercellular adhesion molecule-1 could be a novel biomarker of peritoneal injury in patients on peritoneal dialysis.

摘要

背景

腹膜慢性炎症会导致腹膜透析患者出现腹膜损伤。细胞间黏附分子-1及其循环形式可溶性细胞间黏附分子-1在炎症中起关键作用。然而，它们在腹膜损伤中的作用尚不清楚。

方法

我们测量了大鼠腹膜损伤模型腹膜中细胞间黏附分子-1表达的变化。在94份腹膜透析引流液样本中，研究了引流液中可溶性细胞间黏附分子-1水平与通过腹膜平衡试验测定的溶质转运率（D/P-肌酐和D/D0-葡萄糖）以及引流液中基质金属蛋白酶-2水平之间的关联。

结果

腹膜损伤大鼠的腹膜中细胞间黏附分子-1表达增加。引流液中可溶性细胞间黏附分子-1水平与D/P-肌酐显著正相关（r = 0.51，p < 0.01），与D/D0-葡萄糖呈负相关（r = -0.44，p < 0.01）。它们还与引流液中基质金属蛋白酶-2水平显著正相关（r = 0.86，p < 0.01）。