Wang Yuxuan, Wang Chengcheng, Zhang Xiuli, Gu Harvest F, Wu Liang
School of Life Science and Technology, China Pharmaceutical University, Nanjing, 210009, China.
Jiangsu Key Laboratory of Drug Screening, China Pharmaceutical University, Nanjing, 210009, China.
Curr Diabetes Rev. 2018;14(2):149-161. doi: 10.2174/1573399813666170214112115.
Diabetic nephropathy is characterized by hypertension, progressive albuminuria, glomerulosclerosis and declines in glomerular filtration rate leading to end stage renal disease. Although the pathogenesis of diabetic nephropathy is not fully understood, current treatment of the patients with diabetic nephropathy is mainly based upon the control of hyperglycaemia and management of blood pressures.
Several drugs, which are originally developed for hypertension therapy, have been adopted for stabilization of renal function in diabetic nephropathy. In this review, we first discussed the relationships between diabetic nephropathy and hypertension particularly in the renin-angiotensinaldosterone system. We then summarized chemical structures, pharmacological characteristics and clinical studies of the common drugs used for treatment of diabetic nephropathy, while these drugs have effects against hypertension.
This review may provide the constructive information for further drug development in diabetic nephropathy.
糖尿病肾病的特征为高血压、进行性蛋白尿、肾小球硬化以及肾小球滤过率下降，最终导致终末期肾病。尽管糖尿病肾病的发病机制尚未完全明确，但目前对糖尿病肾病患者的治疗主要基于血糖控制和血压管理。
几种最初用于高血压治疗的药物已被用于稳定糖尿病肾病患者的肾功能。在本综述中，我们首先讨论了糖尿病肾病与高血压之间的关系，特别是在肾素-血管紧张素-醛固酮系统方面。然后，我们总结了用于治疗糖尿病肾病的常用药物的化学结构、药理特性和临床研究，这些药物同时也具有抗高血压作用。
本综述可为糖尿病肾病的进一步药物研发提供建设性信息。
