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Urinary Concentrations of Bisphenols and Their Association with Biomarkers of Oxidative Stress in People Living Near E-Waste Recycling Facilities in China.居住在中国电子废物回收设施附近人群的尿液中双酚类物质浓度及其与氧化应激生物标志物的关联。
Environ Sci Technol. 2016 Apr 5;50(7):4045-53. doi: 10.1021/acs.est.6b00032. Epub 2016 Mar 18.
2
Modification of the association of bisphenol A with abnormal liver function by polymorphisms of oxidative stress-related genes.氧化应激相关基因多态性对双酚A与肝功能异常关联的影响
Environ Res. 2016 May;147:324-30. doi: 10.1016/j.envres.2016.02.026. Epub 2016 Feb 27.
3
Influence of α-tocopherol and α-lipoic acid on bisphenol-A-induced oxidative damage in liver and ovarian tissue of rats.α-生育酚和α-硫辛酸对双酚A诱导的大鼠肝脏和卵巢组织氧化损伤的影响。
Toxicol Ind Health. 2016 Aug;32(8):1381-1390. doi: 10.1177/0748233714563433. Epub 2014 Dec 29.
4
Associations between urinary phenol and paraben concentrations and markers of oxidative stress and inflammation among pregnant women in Puerto Rico.波多黎各孕妇尿中苯酚和对羟基苯甲酸酯浓度与氧化应激和炎症标志物之间的关联。
Int J Hyg Environ Health. 2015 Mar;218(2):212-9. doi: 10.1016/j.ijheh.2014.11.001. Epub 2014 Nov 18.
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The effect of bisphenol A on some oxidative stress parameters and acetylcholinesterase activity in the heart of male albino rats.双酚A对雄性白化大鼠心脏某些氧化应激参数及乙酰胆碱酯酶活性的影响。
Cytotechnology. 2015 Jan;67(1):145-55. doi: 10.1007/s10616-013-9672-1. Epub 2013 Dec 12.
6
Urinary bisphenol A concentrations are associated with abnormal liver function in the elderly: a repeated panel study.尿中双酚A浓度与老年人肝功能异常相关：一项重复横断面研究。
J Epidemiol Community Health. 2014 Apr;68(4):312-7. doi: 10.1136/jech-2013-202548. Epub 2013 Nov 27.
7
eNOS gene polymorphisms modify the association of PM(10) with oxidative stress.eNOS 基因多态性改变了 PM(10)与氧化应激的关联。
Toxicol Lett. 2012 Nov 15;214(3):263-7. doi: 10.1016/j.toxlet.2012.09.006. Epub 2012 Sep 13.
8
Bisphenol A induces hepatotoxicity through oxidative stress in rat model.双酚 A 通过氧化应激在大鼠模型中诱导肝毒性。
Oxid Med Cell Longev. 2012;2012:194829. doi: 10.1155/2012/194829. Epub 2012 Jul 24.
9
Canned soup consumption and urinary bisphenol A: a randomized crossover trial.罐装汤的摄入量与尿中双酚A：一项随机交叉试验。
JAMA. 2011 Nov 23;306(20):2218-20. doi: 10.1001/jama.2011.1721.
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Lead and bisphenol A concentrations in the Canadian population.加拿大人群中铅和双酚 A 的浓度。
Health Rep. 2010 Sep;21(3):7-18.

双酚A暴露导致尿丙二醛水平升高：一项纵向队列研究。

Increase of urinary malondialdehyde level by bisphenol A exposure: a longitudinal panel study.

作者信息

Kim Jin Hee, Hong Yun-Chul

机构信息

Department of Integrative Bioscience & Biotechnology, Sejong University, 209 Neungdong-ro, Gwangjin-gu, Seoul, Republic of Korea.

Department of Preventive Medicine, Seoul National University College of Medicine, 28 Yongon-dong, Chongno-gu, Seoul, Republic of Korea.

出版信息

Environ Health. 2017 Feb 15;16(1):8. doi: 10.1186/s12940-017-0221-9.

DOI:10.1186/s12940-017-0221-9
PMID:28202054
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5312571/
Abstract

BACKGROUND

To verify oxidative stress as a possible mechanism that establishes a relationship between exposure to bisphenol A (BPA) and adverse health outcomes in the elderly Korean population, we evaluated the relation between visit-to-visit variations in urinary BPA and oxidative stress biomarker.

METHODS

To assess the relation between BPA and urinary malondialdehyde (MDA) as an oxidative stress biomarker, we used a mixed effect model after controlling for age, sex, BMI, drinking status, exercise, urinary cotinine level, PM on lag day 2, and mean temperature and dew point on the day. The relation between exposure to BPA and MDA level by sex of participants and polymorphisms of oxidative stress-related genes (COX2, EPHX1, HSP70-hom, PON1, eNOS, CAT, DRD2, SOD2, and MPO) was also evaluated.

RESULTS

A significant association was found for BPA with MDA in both male and female elderly participants (male, β = 0.19 and p = 0.0003; female, β = 0.18 and p < .0001; and total, β = 0.18 and p < .0001). Furthermore, the association of BPA with MDA was found regardless of any genotype of the nine oxidative stress-related genes.

CONCLUSIONS

The results of our study suggest a strong association of BPA with oxidative stress, not related with sex and oxidative stress-related gene polymorphisms.

摘要

背景

为验证氧化应激是否是建立韩国老年人群双酚A（BPA）暴露与不良健康结局之间关系的一种可能机制，我们评估了尿BPA访视间变化与氧化应激生物标志物之间的关系。

方法

为评估BPA与作为氧化应激生物标志物的尿丙二醛（MDA）之间的关系，我们在控制了年龄、性别、体重指数、饮酒状况、运动、尿可替宁水平、滞后2天的颗粒物（PM）以及当天的平均温度和露点后，使用了混合效应模型。还评估了参与者性别和氧化应激相关基因（COX2、EPHX1、HSP70-hom、PON1、eNOS、CAT、DRD2、SOD2和MPO）多态性对BPA暴露与MDA水平之间关系的影响。

结果

在老年男性和女性参与者中均发现BPA与MDA存在显著关联（男性，β = 0.19，p = 0.0003；女性，β = 0.18，p < 0.0001；总体，β = 0.18，p < 0.0001）。此外，无论九个氧化应激相关基因的任何基因型如何，均发现BPA与MDA存在关联。

结论

我们的研究结果表明BPA与氧化应激之间存在强关联，且与性别和氧化应激相关基因多态性无关。