Salimi Z, Wolverson M K, Herbold D R, Vas W, Salimi A
AJR Am J Roentgenol. 1987 Oct;149(4):773-6. doi: 10.2214/ajr.149.4.773.
Experiments were conducted in 32 rabbits to determine whether treatment with IV streptokinase can effectively limit the extent of tissue damage associated with frostbite injury of the hind limbs. Other variables studied were the temperature of the tissue during freezing, the time taken to rewarm the exposed limbs, and the delay between the initiation of treatment with streptokinase and cessation of freezing. A control group of 16 rabbits was not given streptokinase. The extent of tissue damage was estimated by sequential radionuclide perfusion scans of the exposed limbs. This estimate was based on the proportional loss of tissue perfusion on subsequent twice-weekly nuclear scans in comparison with that shown by scans performed immediately after thawing. Pathologic changes in exposed tissues were studied by histology. Streptokinase treatment and rapid rewarming both resulted in less tissue damage at all freezing temperatures. Streptokinase was most beneficial when given 12 hr after freezing, but was effective even when treatment was delayed up to 48 hr.
对32只兔子进行了实验，以确定静脉注射链激酶治疗是否能有效限制与后肢冻伤相关的组织损伤程度。研究的其他变量包括冷冻期间组织的温度、使暴露肢体复温所需的时间，以及开始使用链激酶治疗与停止冷冻之间的延迟时间。16只兔子的对照组未接受链激酶治疗。通过对暴露肢体进行连续放射性核素灌注扫描来估计组织损伤程度。该估计基于与解冻后立即进行的扫描相比，后续每周两次的核扫描中组织灌注的比例损失。通过组织学研究暴露组织的病理变化。在所有冷冻温度下，链激酶治疗和快速复温均导致较少的组织损伤。链激酶在冷冻后12小时给药时最有益，但即使治疗延迟长达48小时也有效。
