Knudsen G M, Christensen H, Berild D, Melgaard B, Kirkegaard C, Hasselbalch H
Alcohol Clin Exp Res. 1987 Aug;11(4):323-5. doi: 10.1111/j.1530-0277.1987.tb01318.x.
An insulin hypoglycemia test and a 30-min ACTH stimulation test was performed in 10 chronic alcoholic men, who had been abstinent from alcohol for at least one month. Attenuated serum cortisol responses were found in six of the patients despite a normal ACTH test. Four patients showed normal responses to both the insulin hypoglycemia test and the short ACTH test. No correlation was demonstrated between the cortisol response and the severity of alcoholism, cerebral atrophy, and peripheral neuropathy. It is concluded that in chronic alcoholism the short ACTH test may fail in disclosing hypofunction of the integrated hypothalamic-pituitary-adrenocortical (HPA) axis as assessed with the insulin hypoglycemia test.
对10名慢性酒精中毒男性进行了胰岛素低血糖试验和30分钟促肾上腺皮质激素（ACTH）刺激试验，这些男性已戒酒至少1个月。尽管ACTH试验结果正常，但6名患者的血清皮质醇反应减弱。4名患者对胰岛素低血糖试验和短程ACTH试验均表现出正常反应。皮质醇反应与酒精中毒的严重程度、脑萎缩和周围神经病变之间未显示出相关性。结论是，在慢性酒精中毒中，短程ACTH试验可能无法揭示如胰岛素低血糖试验所评估的下丘脑-垂体-肾上腺皮质（HPA）轴的功能减退。
