Rao Wenwang, Zhou Na, Zhang Huiping, Liu Rui, Zhang Shangchao, Su Yingying, Yang Guang, Ma Yue, Shi Jieping, Yu Yaqin, Yu Qiong
Department of Epidemiology and Biostatistics, School of Public Health, Jilin University, Changchun, China.
Department of Epidemiology and Biostatistics, School of Public Health, Jilin University, Changchun, China; Department of Pharmacy, Stomatology Hospital, Jilin University, Changchun 130041, China.
Dis Markers. 2017;2017:3104180. doi: 10.1155/2017/3104180. Epub 2017 Jan 19.
Our previous studies using the mass spectrum analysis provided evidence that fibrinopeptide A (FPA) could be a potential biomarker for schizophrenia diagnosis. We sought further to demonstrate that variants in the fibrinogen alpha chain gene coded FPA might confer vulnerability to schizophrenia. 1,145 patients with schizophrenia and 1,016 healthy volunteers from the Han population in Northeast China were recruited. The association of three tag single nucleotide polymorphisms (SNPs) (rs2070011 in the 5'UTR, rs2070016 in intron 4, and rs2070022 in the 3'UTR) in and schizophrenia was examined using a case-control study design. Genotypic distributions of these three SNPs were not found to be significantly different between cases and controls (rs2070011: = 1.28, = 0.528; rs2070016: = 4.11, = 0.128; rs2070022: = 1.23, = 0.541). There were also no significant differences in SNP allelic frequencies between cases and controls (all > 0.05). Additionally, the frequency of haplotypes consisting of alleles of these three SNPs was not significantly different between cases and healthy control subjects (global = 9.27, = 0.159). Our study did not show a significant association of SNPs with schizophrenia. Future studies may need to test more SNPs in a larger sample to identify those SNPs with a minor or moderate effect on schizophrenia.
我们之前使用质谱分析的研究提供了证据，表明纤维蛋白肽A（FPA）可能是精神分裂症诊断的潜在生物标志物。我们进一步试图证明，编码FPA的纤维蛋白原α链基因中的变异可能使个体易患精神分裂症。招募了来自中国东北汉族人群的1145例精神分裂症患者和1016名健康志愿者。采用病例对照研究设计，检测了纤维蛋白原α链基因中的三个标签单核苷酸多态性（SNP）（5'UTR中的rs2070011、内含子4中的rs2070016和3'UTR中的rs2070022）与精神分裂症的关联。未发现这三个SNP的基因型分布在病例组和对照组之间存在显著差异（rs2070011：χ² = 1.28，P = 0.528；rs2070016：χ² = 4.11，P = 0.128；rs2070022：χ² = 1.23，P = 0.541）。病例组和对照组之间的SNP等位基因频率也没有显著差异（所有P > 0.05）。此外，由这三个SNP的等位基因组成的单倍型频率在病例组和健康对照组之间没有显著差异（全局χ² = 9.27，P = 0.159）。我们的研究未显示纤维蛋白原α链基因的SNP与精神分裂症有显著关联。未来的研究可能需要在更大的样本中检测更多的纤维蛋白原α链基因SNP，以确定那些对精神分裂症有轻微或中等影响的SNP。
