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血浆置换治疗药物性胆汁淤积所致难治性瘙痒

Plasmapheresis for Refractory Pruritus due to Drug-Induced Cholestasis.

作者信息

Al-Azzawi Hasan, Patel Ruchi, Sood Gagan, Kapoor Sumit

机构信息

Department of Pulmonary, Critical Care and Sleep, Baylor College of Medicine, Houston, TX, USA.

Department of Abdominal Transplantation, Baylor College of Medicine, Houston, TX, USA.

出版信息

Case Rep Gastroenterol. 2017 Jan 6;10(3):814-818. doi: 10.1159/000454674. eCollection 2016 Sep-Dec.

DOI:10.1159/000454674
PMID:28203129
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5260533/
Abstract

Pruritus can be a distressing symptom seen in various cholestatic disorders. It is treated with medications like bile acid sequestrants. Drug-induced cholestasis usually resolves with withdrawal of the causative medication. We describe a case of refractory pruritus due to drug-induced cholestasis, not improved with withdrawal of the drug, managed effectively with multiple sessions of plasmapheresis.

摘要

瘙痒是各种胆汁淤积性疾病中出现的一种令人苦恼的症状。可使用胆汁酸螯合剂等药物进行治疗。药物性胆汁淤积通常在停用致病药物后缓解。我们描述了一例因药物性胆汁淤积导致的难治性瘙痒病例，停药后未改善，通过多次血浆置换有效治疗。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c930/5260533/5c595a533bdf/crg-0010-0814-g02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c930/5260533/02752de178a8/crg-0010-0814-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c930/5260533/5c595a533bdf/crg-0010-0814-g02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c930/5260533/02752de178a8/crg-0010-0814-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c930/5260533/5c595a533bdf/crg-0010-0814-g02.jpg

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本文引用的文献

1
Pruritus in chronic cholestatic liver disease.慢性胆汁淤积性肝病中的瘙痒。
Clin Liver Dis. 2012 May;16(2):331-46. doi: 10.1016/j.cld.2012.03.010.
2
Extracorporeal artificial liver support systems in the management of intractable cholestatic pruritus.体外人工肝支持系统在顽固性胆汁淤积性瘙痒症治疗中的应用。
Liver Int. 2011 Sep;31 Suppl 3:31-3. doi: 10.1111/j.1478-3231.2011.02584.x.
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Drug-induced cholestasis.药物性胆汁淤积。
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Plasma separation and anion adsorption transiently relieve intractable pruritus in primary biliary cirrhosis.血浆分离和阴离子吸附可短暂缓解原发性胆汁性肝硬化的顽固性瘙痒。
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Cholestasis induced by parabolan successfully treated with the molecular adsorbent recirculating system.用分子吸附循环系统成功治疗了司坦唑醇诱导的胆汁淤积。
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Plasmapheresis for the treatment of intrahepatic cholestasis of pregnancy refractory to medical treatment.血浆置换治疗药物治疗无效的妊娠肝内胆汁淤积症。
Am J Obstet Gynecol. 2005 Jun;192(6):2088-9. doi: 10.1016/j.ajog.2005.01.048.
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Hepatology. 2005 Jun;41(6):1407-32. doi: 10.1002/hep.20704.
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Drug-induced liver disease.药物性肝病
Med Clin North Am. 2000 Sep;84(5):1275-311, x. doi: 10.1016/s0025-7125(05)70287-x.