胃肠道间质瘤伴同时性骨转移：一例报告及文献复习

Rochigneux Philippe, Mescam-Mancini Lénaig, Perrot Delphine, Bories Erwan, Moureau-Zabotto Laurence, Sarran Anthony, Guiramand Jérôme, Bertucci François

Department of Medical Oncology, Institut Paoli-Calmettes, Marseille, France.

Department of Pathology, Institut Paoli-Calmettes, Marseille, France.

Case Rep Oncol. 2017 Jan 17;10(1):66-76. doi: 10.1159/000455188. eCollection 2017 Jan-Apr.

Gastrointestinal stromal tumours (GISTs) are mesenchymal tumours of the digestive tract, derived from Cajal interstitial cells. Bone metastases are very rare, and there is no consensus regarding their treatment. Here, we present the unusual case of a 66-year-old man with a gastric GIST with synchronous bone and liver metastases, fully documented at the pathological and molecular levels with a exon 11 mutation. After 9 months of imatinib, the scanner showed a 33% partial response of target lesions. We also review the literature and describe the characteristics, treatment, and outcome of all cases previously reported.

胃肠道间质瘤（GISTs）是起源于消化道间叶组织的肿瘤，由卡哈尔间质细胞衍生而来。骨转移非常罕见，关于其治疗尚无共识。在此，我们报告一例罕见病例，一名66岁男性患有胃GIST并伴有同步骨和肝转移，在病理和分子水平均有充分记录，存在外显子11突变。接受伊马替尼治疗9个月后，扫描显示靶病灶部分缓解33%。我们还回顾了文献，并描述了先前报道的所有病例的特征、治疗及结果。