Effect of peritoneal dialysis fluids on activity of echinocandins against Candida spp. biofilm.
作者信息
Tobudic Selma, Harrison Nicole, Forstner Christina, Kussman Manuel, Burgmann Heinz
机构信息
Department of Internal Medicine I, Division of Infectious Diseases and Tropical Medicine, Medical University of Vienna, Währinger Guertel 18-20, 1090 Vienna, Austria.
Center for Infectious Diseases and Infection Control, Jena University Hospital, Erlanger Allee 101, 07749 Jena, Germany.
出版信息
Med Mycol. 2017 Oct 1;55(7):790-793. doi: 10.1093/mmy/myw145.
Peritoneal dialysis fluids (PDFs) impair microorganisms' growth, which may compromise effectivity of some antimicrobials. The purpose of this study was to investigate the effect of three different PDFs (lactate/bicarbonate-buffered Physioneal 40® with 2.2% glucose, lactate-buffered Nutrineal PD4® with 1.1% amino acid, and lactate-buffered Extraneal® with 7.5% icodextrin) on biofilm formation of four different Candida spp and antibiofilm effectiveness of anidulafungin, caspofungin and micafungin against Candida spp. biofilm in PDFs. All tested PDFs attained inhibitory effect on the biofilm formation but also reduced biofilm effectiveness of echinocandins against biofilm in PDFs was detected.
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