Transplantation-Oncology Infectious Diseases Program, Division of Infectious Diseases, Weill Cornell Medical Center of Cornell University, New York, New York.
Infectious Disease Unit, Third Department of Pediatrics, Faculty of Medicine, Aristotle University School of Health Sciences, Hippokration Hospital, Thessaloniki, Greece.
Clin Infect Dis. 2015 Dec 1;61 Suppl 6:S622-9. doi: 10.1093/cid/civ746.
Biofilm-related infections have become an increasingly important clinical problem. Many of these infections occur in patients with multiple comorbidities or with impaired immunity. Echinocandins (caspofungin, micafungin, and anidulafungin) exert their fungicidal activity by inhibition of the synthesis of the (1→3)-β-d-glucan. They are active among in vitro and in vivo model systems against a number of Candida species and filamentous fungi in their planktonic and biofilm phenotype. Their superior activity against biofilms poses them in an advantageous position among the antifungal armamentarium. However, additional studies are warranted to expand our knowledge on the role of echinocandins against biofilm-related infections.
生物膜相关感染已成为一个日益重要的临床问题。这些感染中有许多发生在患有多种合并症或免疫功能受损的患者中。棘白菌素（卡泊芬净、米卡芬净和阿尼芬净）通过抑制（1→3）-β-d-葡聚糖的合成发挥杀菌作用。它们在体外和体内模型系统中对多种念珠菌属和丝状真菌的浮游和生物膜表型均具有活性。它们对生物膜的优越活性使它们在抗真菌药物中处于有利地位。然而，需要进一步的研究来扩展我们对棘白菌素在生物膜相关感染中的作用的认识。
