Menon I A, Basu P K, Persad S, Avaria M, Felix C C, Kalyanaraman B
Clinical Science Division, Faculty of Medicine, University of Toronto, Canada.
Br J Ophthalmol. 1987 Jul;71(7):549-52. doi: 10.1136/bjo.71.7.549.
Investigations were carried out to determine whether the melanin present in the blue and brown eyes were eumelanin, the melanin present in black hair and dark skin, or pheomelanin, the melanin present in red hair and the skin of people with red hair. Our results showed that UV-visible irradiation of blue or brown eye melanin did not produce any superoxide. Irradiation of 51Cr-labelled Ehrlich ascites carcinoma cells in the presence of blue or brown eye melanin did not produce significant cell lysis. The electron spin resonance (ESR) signals of blue and brown eye melanins were very similar to those of eumelanin. Comparison of these findings with our previous results indicated that the blue and brown eye melanins are essentially eumelanin. The ESR signals further suggested that in the case of both blue and brown eye melanins the iris, ciliary body, choroid, and retinal pigment epithelium did not differ.
开展了多项研究，以确定蓝眼睛和棕眼睛中存在的黑色素是真黑素（即存在于黑色头发和深色皮肤中的黑色素），还是褐黑素（即存在于红色头发和红发人群皮肤中的黑色素）。我们的结果表明，对蓝眼睛或棕眼睛黑色素进行紫外可见照射不会产生任何超氧化物。在蓝眼睛或棕眼睛黑色素存在的情况下，对51Cr标记的艾氏腹水癌细胞进行照射不会产生显著的细胞裂解。蓝眼睛和棕眼睛黑色素的电子自旋共振（ESR）信号与真黑素的信号非常相似。将这些发现与我们之前的结果进行比较表明，蓝眼睛和棕眼睛黑色素本质上都是真黑素。ESR信号进一步表明，对于蓝眼睛和棕眼睛黑色素而言，虹膜、睫状体、脉络膜和视网膜色素上皮并无差异。
