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慢性疼痛患者中处方类阿片和医用大麻的滥用问题。

Problematic Use of Prescription Opioids and Medicinal Cannabis Among Patients Suffering from Chronic Pain.

机构信息

Dual Diagnosis Clinic, Lev-Hasharon Medical Center, Pardesiya, Israel.

Pain Center, Sheba Medical Center, Tel Hashomer, Israel.

出版信息

Pain Med. 2017 Feb 1;18(2):294-306. doi: 10.1093/pm/pnw134.

Abstract

OBJECTIVE

To assess prevalence rates and correlates of problematic use of prescription opioids and medicinal cannabis (MC) among patients receiving treatment for chronic pain.

DESIGN

Cross-sectional study.

SETTING

Two leading pain clinics in Israel.

SUBJECTS

Our sample included 888 individuals receiving treatment for chronic pain, of whom 99.4% received treatment with prescription opioids or MC.

METHODS

Problematic use of prescription opioids and MC was assessed using DSM-IV criteria, Portenoy’s Criteria (PC), and the Current Opioid Misuse Measure (COMM) questionnaire. Additional sociodemographic and clinical correlates of problematic use were also assessed.

RESULTS

Among individuals treated with prescription opioids, prevalence of problematic use of opioids according to DSM-IV, PC, and COMM was 52.6%, 17.1%, and 28.7%, respectively. Among those treated with MC, prevalence of problematic use of cannabis according to DSM-IV and PC was 21.2% and 10.6%, respectively. Problematic use of opioids and cannabis was more common in individuals using medications for longer periods of time, reporting higher levels of depression and anxiety, and using alcohol or drugs. Problematic use of opioids was associated with higher self-reported levels of pain, and problematic use of cannabis was more common among individuals using larger amounts of MC.

CONCLUSIONS

Problematic use of opioids is common among chronic pain patients treated with prescription opioids and is more prevalent than problematic use of cannabis among those receiving MC. Pain patients should be screened for risk factors for problematic use before initiating long-term treatment for pain-control.

摘要

目的

评估接受慢性疼痛治疗的患者中处方类阿片和医用大麻(MC)的问题性使用的流行率和相关因素。

设计

横断面研究。

地点

以色列的两家领先的疼痛诊所。

研究对象

我们的样本包括 888 名接受慢性疼痛治疗的患者,其中 99.4%接受处方类阿片或 MC 治疗。

方法

使用 DSM-IV 标准、Portenoy 标准(PC)和当前阿片类药物滥用测量表(COMM)问卷评估处方类阿片和 MC 的问题性使用。还评估了其他社会人口统计学和临床相关因素。

结果

在接受处方类阿片治疗的患者中,根据 DSM-IV、PC 和 COMM,阿片类药物问题性使用的患病率分别为 52.6%、17.1%和 28.7%。在接受 MC 治疗的患者中,根据 DSM-IV 和 PC,大麻问题性使用的患病率分别为 21.2%和 10.6%。使用药物时间较长、报告更高水平的抑郁和焦虑、以及使用酒精或药物的患者,阿片类药物和大麻的问题性使用更为常见。阿片类药物的问题性使用与更高的自我报告疼痛水平相关,而大麻的问题性使用在使用更多 MC 的患者中更为常见。

结论

接受处方类阿片治疗的慢性疼痛患者中,阿片类药物的问题性使用很常见,且比接受 MC 治疗的患者中,大麻的问题性使用更为普遍。在开始长期疼痛控制治疗之前,应筛查疼痛患者是否存在问题性使用的风险因素。

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