脑啡肽对动脉血压的作用被普萘洛尔减弱。

Effects of enkephalins on arterial blood pressure are reduced by propranolol.

Simon W, Schaz K, Ganten U, Stock G, Schlör K H, Ganten D

Clin Sci Mol Med Suppl. 1978 Dec;4:237s-241s. doi: 10.1042/cs055237s.

Abstract

The cardiovascular effects of enkephalins have been tested in normotensive Wistar-Kyoto rats. Methionine-enkephalin and leucine-enkephalin increased blood pressure and heart rate after infusion into the brain ventricles. 2. After intravenous injection, blood pressure was increased by methionine-enkephalin and leucine-enkephalin, but heart rate was increased by methionine-enkephalin only. 3. Propranolol treatment reduced the increases in blood pressure following intraventricular methionine-enkephalin and leucine-enkephalin, while only the methionine-enkephalin-induced increases in heart rate were reduced by propranolol. 4. Heart rate and blood pressure responses after intravenous administration of methionine-enkephalins and leucine-enkephalin were not affected by propranolol. 5. Since opioid peptides occur in the blood and in regions of the brain involved in blood pressure regulation, the demonstrated cardiovascular effects to intraventricular and intravenous enkephalins support a role of these peptides in central and peripheral mechanisms of blood pressure control.

摘要

脑啡肽对心血管系统的影响已在正常血压的Wistar-Kyoto大鼠中进行了测试。将甲硫氨酸脑啡肽和亮氨酸脑啡肽注入脑室后，血压和心率升高。2. 静脉注射后，甲硫氨酸脑啡肽和亮氨酸脑啡肽使血压升高，但仅甲硫氨酸脑啡肽使心率升高。3. 普萘洛尔治疗可降低脑室内注射甲硫氨酸脑啡肽和亮氨酸脑啡肽后血压的升高，而普萘洛尔仅降低甲硫氨酸脑啡肽引起的心率升高。4. 静脉注射甲硫氨酸脑啡肽和亮氨酸脑啡肽后的心率和血压反应不受普萘洛尔影响。5. 由于阿片肽存在于血液以及参与血压调节的脑区中，已证实的脑室内和静脉注射脑啡肽对心血管系统的影响支持了这些肽在血压控制的中枢和外周机制中发挥作用。